New Approaches for Efficiency in the Synthesis of Organic Compounds

这项研究的重点是扩大化学的基本设置， 有机化学家可以利用的反应， 复杂分子的合成。有五个集中领域。 第一个是发展加成反应的基础上， 乙炔与过渡金属的优异配位化学。在 在这种情况下，将出现新的环加成反应类别， 快速构建分子复杂性。第二个领域涉及 烯丙基钯化学，其中一系列模块化设计的配体 控制绝对立体化学或手性。第三个领域涉及 硅促进碳-碳键形成的能力。的 第四个领域探讨了膦作为新型催化剂的发展。 最后，第五个领域建立在硫的多功能性基础上， 不寻常的反应性，特别是在砜和硫离子。与此 奖，合成有机计划是支持博士的研究。 巴里M.斯坦福大学化学系的特罗斯特说。 特罗斯特教授将把工作重点放在开发高效的合成 适用于复杂有机方法的方法 具有理论和生物学意义的分子。使用 金属有机中间体，催化和化学计量，是 在工作中强调。

The focus of this research is to expand the basic set of chemical reactions available to the organic chemist for application to the synthesis of complex molecules. There are five areas of concentration. The first is the development of addition reactions based upon the excellent coordination chemistry of acetylenes with transition metals. In this context, new classes of cycloaddition reactions will emerge which build molecular complexity rapidly. The second area involves allylpalladium chemistry whereby a series of modularly designed ligands controls absolute stereochemistry or chirality. The third area involves the ability of silicon to promote carbon-carbon bond formation. The fourth area probes the development of phosphines as novel catalysts. Finally, the fifth area builds upon the versatility of sulfur to impart unusual reactivity, especially in sulfones and sulfenium ions. With this award, the Synthetic Organic Program is supporting the research of Dr. Barry M. Trost of the Department of Chemistry at Stanford University. Professor Trost will focus his work on developing efficient synthetic methodology which is applicable to approaches to complex organic molecules of theoretical and biological interest. The use of organometallic intermediates, both catlytic and stoichiometric, is stressed in the work.