New Approaches for Efficiency in the Synthesis of Organic Compounds

提高有机化合物合成效率的新方法

• 批准号: 9501472
• 负责人: Barry Trost
• 金额: $ 184.74万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-01-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9501472&HistoricalAwards=false
• 关键词: New; Approaches; Efficiency; Synthesis; Organic

The focus of this research is to expand the basic set of chemical reactions available to the organic chemist for application to the synthesis of complex molecules. There are five areas of concentration. The first is the development of addition reactions based upon the excellent coordination chemistry of acetylenes with transition metals. In this context, new classes of cycloaddition reactions will emerge which build molecular complexity rapidly. The second area involves allylpalladium chemistry whereby a series of modularly designed ligands controls absolute stereochemistry or chirality. The third area involves the ability of silicon to promote carbon-carbon bond formation. The fourth area probes the development of phosphines as novel catalysts. Finally, the fifth area builds upon the versatility of sulfur to impart unusual reactivity, especially in sulfones and sulfenium ions. With this award, the Synthetic Organic Program is supporting the research of Dr. Barry M. Trost of the Department of Chemistry at Stanford University. Professor Trost will focus his work on developing efficient synthetic methodology which is applicable to approaches to complex organic molecules of theoretical and biological interest. The use of organometallic intermediates, both catlytic and stoichiometric, is stressed in the work.

本研究的重点是扩展基本的化学反应集，使有机化学家可以应用于复杂分子的合成。这里有五个重点领域。第一个是基于乙炔与过渡金属良好的配位化学的加成反应的发展。在这种情况下，新的类环加成反应将出现，迅速建立分子复杂性。第二个领域涉及烯丙基钯化学，通过一系列模块化设计的配体控制绝对立体化学或手性。第三个领域涉及硅促进碳-碳键形成的能力。第四部分探讨了磷化氢作为新型催化剂的发展。最后，第五个领域建立在硫的多功能性上，赋予了不同寻常的反应性，特别是在砜和硫离子中。通过这个奖项，合成有机项目支持了斯坦福大学化学系的Barry M. Trost博士的研究。Trost教授将专注于开发高效的合成方法，该方法适用于具有理论和生物学意义的复杂有机分子。有机金属中间体的使用，包括催化和化学计量，在工作中强调。