Purchase of an LC-Electrospray Mass Spectrometer

购买 LC 电喷雾质谱仪

• 批准号: 9214863
• 负责人: William Miller
• 金额: $ 16.66万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-01-01 至 1993-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9214863&HistoricalAwards=false
• 关键词: Purchase; LC; Electrospray; Mass; Spectrometer

This award will assist the College of Chemistry at the University of California Berkeley in the purchase of a triple quadrupole mass spectrometer equipped with electro- spray ionization capabilities and interfaced liquid chromatograph. The instrument is needed by members of the Department of Chemistry and will also provide mass spectroscopic services for the Department of Molecular Biology. Research areas supported by the acquisition of this instrument are: 1) Structure determination of protein-bound pigments. 2) Analysis of charged high molecular weight fullerene derivatives. 3) Design and synthesis of new classes of synthetic biopolymers. 4) Linkage position determination of metal-coordinated oligosaccharides. 5) Site specific incorporation of unnatural amino acids in proteins. 6) Analysis of densely charged poly-onium compounds. 7) Preparation of peptides with defined secondary structure. 8) Structure determination of transcription factors. 9) Structure determination of RNA molecules. %%% A mass spectrometer is an instrument used to measure the precise molecular weight of a molecule. The electrospray device is a way to volatilize the sample so that it may be introduced into the mass spectrometer. This information is needed so that the chemical composition and, sometimes, the molecular structure of newly synthesized compounds may be determined. An instrument of this description is required in the Berkeley facility because the current user needs cannot be meet with the existing equipment.

该奖项将协助化学学院在 加州伯克利大学购买了 三重四极杆质谱仪配备电 喷雾 电离 能力 和 界面液体 色谱仪。该文书是联合国各成员国需要的， 部 化学 并将 还提供质量 为分子生物学系提供光谱服务 生物学收购本公司所支持的研究领域 这些工具是： 1)蛋白质结合色素的结构测定。 2)带电高分子量富勒烯的分析 衍生物. 3)设计与合成 新型合成材料 生物聚合物 4)连杆位置 金属配位测定 低聚糖。 5)非天然氨基酸的位点特异性掺入 proteins. 6)密电荷多鎓化合物的分析。 7)具有确定二级结构的肽的制备。 8)转录因子的结构决定。 9)RNA分子的结构测定。 %%% 质谱仪是用来测量 分子的精确分子量电喷雾 设备是一种挥发样品的方法， 引入质谱仪。 该信息 需要这样的化学成分，有时， 新合成的化合物的分子结构可能 测定在下列情况下， 伯克利设施，因为目前的用户需求不能 满足现有设备。