Acquisition of a GC-MS with Chemical Ionization and Positive/Negative Ion Detection Capability

获得具有化学电离和正/负离子检测能力的 GC-MS

• 批准号: 9217718
• 负责人: Alvin Fox
• 金额: $ 3.5万
• 依托单位: University of South Carolina at Columbia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-15 至 1996-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9217718&HistoricalAwards=false
• 关键词: Acquisition; GC; MS; Chemical; Ionization

This proposal is a request for ancillary equipment that is essential for the optimal operation of two tandem mass spectrometers used for carbohydrate research. Modern research grade MS and MS-MS instruments are all designed to be run routinely in both electrospray (ESI) mode (for liquid chromatography, i.e., LC-MS or LC-MS-MS) and electron impact/chemical ionization (EI/CI) mode (for gas chromatography, i.e., GC-MS or GC-MS-MS). Analysis of carbohydrates by conventional LC has made great progress in recent years. A new LC system has been developed involving a patented ion exchange column and pulsed amperometric detector (PAD) which has become the "gold standard" in sugar analysis. Obtaining this LC will allow us to extend from ESI-MS-MS into the field of ESI-MS-MS. This represents the state-of-the-art in carbohydrate analysis.

本提案是对用于碳水化合物研究的两台串联质谱仪的最佳操作所必需的辅助设备的请求。现代研究级质谱和质谱联用仪器都设计为在电喷雾（ESI）模式（液相色谱，即LC-MS或LC-MS-MS）和电子冲击/化学电离（EI/CI）模式（气相色谱，即GC-MS或GC-MS-MS）下常规运行。近年来，常规液相色谱法对碳水化合物的分析取得了很大的进展。采用离子交换柱和脉冲安培检测器（PAD）组成的新型液相色谱系统已成为糖分析的“金标准”。获得此LC将使我们从ESI-MS-MS扩展到ESI-MS-MS领域。这代表了最先进的碳水化合物分析。