SGER: Hypothalamic Basis for Reproductive Suppression

这项探索性研究小额赠款的目标是 开发可靠和灵敏的推拉灌注技术， 研究自然诱导的生理机制 雌性马立克氏猴的不孕症。 许多种类的 这些灵长类动物濒临灭绝 在他们的专业 社会制度，在野外和野外的群体中， 实验室保持无菌。 次级排卵 当这些女性仍然存在时， 帮助抚养后代 Abbott博士 已经证明了，维持 这些从属雌性的不育状态存在于 大脑的下丘脑区域。 他现在将开发一个 测量神经递质的复杂技术程序 和下丘脑的激素。 结果将 更好地理解社会环境 利用特定的神经机制来调节女性的生育能力 这可以为发展提供更好的基础， 繁殖技术，以加速繁殖这些罕见的 圈养的猴子，并改善规划和管理 重新引入计划，以及改善管理， 剩下的一小部分猴子生活在 南美人。

The goal of this Small Grant for Exploratory Research is to develop a reliable and sensitive push-pull perfusion technique to examine the physiological mechanisms of naturally-induced infertility in female Callitrichid Monkeys. Many species of these primates are highly endangered. In their specialized social system, subordinate females in groups in the wild and in the laboratory are kept infertile. Ovulation in subordinate females is suppressed while these females remain in the presence of a dominant female and help raise their offspring. Dr. Abbott has demonstrated that the physiological mechanism maintaining the infertile state of these subordinate females resides within the hypothalamic region of the brain. He will now develop a sophisticated technical procedure to measure neurotransmitters and hypothalamic hormones in the hypothalamus. The results will lead to a better understanding of how the social environment engages specific neural mechanisms to regulate female fertility. This could provide a better foundation for the development of reproductive techniques to accelerate the breeding of these rare monkeys in captivity and to improve the planning and management of re-introduction programs as well as improve the management of the remaining small number of monkeys living in the wilds of South American.