Synthetic Organosulfur Chemistry

这项研究的重点是天然有机硫化合物和合成有机硫化合物的化学。对大蒜和洋葱及其盟友的大蒜家族成分的持续研究将解决主要调味剂的光学活性问题和酶在其形成中的作用。用于有机合成的新试剂和方法的发明将包括那些基于Ramberg-Backland反应的试剂和方法的发明，以及它们在合成环戊二烯和1，3-乙炔的新路线上的应用。开展具有特殊生理活性的有机硫天然产物和非天然硫化物的全合成。对高活性小分子有机硫化合物的微波光谱进行研究。将进行新的多硫醇的合成，作为配体和/或材料科学中感兴趣的。%有了这个续约奖，合成有机计划将支持纽约州立大学奥尔巴尼分校化学系的Eric Block博士的研究，他将研究天然有机硫化合物和合成有机硫化合物。在天然产品领域，重点将放在高度不稳定的化合物上，这些化合物解释了包括大蒜和洋葱在内的洋葱家族的气味和味道。在合成领域，有机硫化合物将用于生产有助于隔离重金属的新化合物或用于合成新材料。

The focus of this research is the chemistry of both naturally occurring and synthetic organosulfur compounds. Continuing research on the constituents of the Allium family, which contains garlic and onions and their allies, will address the question of optical activity of primary flavorants and the role of enzymes in their formation. The invention of new reagents and methods for organic synthesis will include those based on the Ramberg-Backland reaction and their application to new routes to cyclopentadienes and 1,3-eneynes. The total synthesis of unusual physiologically active organosulfur natural products and unnatural sulfur compounds will be carried out. The microwave spectroscopy of highly reactive small organosulfur compounds will be studied. Synthesis of new polythiols of interest as ligands and/or in material science will be carried out. %%% With this Renewal award, the Synthetic Organic Program is supporting the research of Dr. Eric Block of the Department of Chemistry at SUNY Albany, who will study both naturally occurring and synthetic organosulfur compounds. In the natural product area, the emphasis will be on the highly labile compounds which account for the odor and flavor of the Allium family which includes garlic and onions. In the synthetic area, organosulfur compounds will be utilized in for the production of new compounds useful in sequestering heavy metals or in the synthesis of new materials.