Synthetic Organosulfur Chemistry

有机硫合成化学

• 批准号: 9303866
• 负责人: Eric Block
• 金额: $ 29.55万
• 依托单位: SUNY at Albany
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-15 至 1996-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9303866&HistoricalAwards=false
• 关键词: Synthetic; Organosulfur; Chemistry

The focus of this research is the chemistry of both naturally occurring and synthetic organosulfur compounds. Continuing research on the constituents of the Allium family, which contains garlic and onions and their allies, will address the question of optical activity of primary flavorants and the role of enzymes in their formation. The invention of new reagents and methods for organic synthesis will include those based on the Ramberg-Backland reaction and their application to new routes to cyclopentadienes and 1,3-eneynes. The total synthesis of unusual physiologically active organosulfur natural products and unnatural sulfur compounds will be carried out. The microwave spectroscopy of highly reactive small organosulfur compounds will be studied. Synthesis of new polythiols of interest as ligands and/or in material science will be carried out. %%% With this Renewal award, the Synthetic Organic Program is supporting the research of Dr. Eric Block of the Department of Chemistry at SUNY Albany, who will study both naturally occurring and synthetic organosulfur compounds. In the natural product area, the emphasis will be on the highly labile compounds which account for the odor and flavor of the Allium family which includes garlic and onions. In the synthetic area, organosulfur compounds will be utilized in for the production of new compounds useful in sequestering heavy metals or in the synthesis of new materials.

这项研究的重点是天然存在和合成的有机硫化合物的化学。对葱属家族（包含大蒜和洋葱及其盟友）成分的持续研究将解决主要调味剂的光学活性问题以及酶在其形成中的作用。有机合成新试剂和方法的发明将包括基于 Ramberg-Backland 反应的试剂和方法及其在环戊二烯和 1,3-烯炔新路线中的应用。开展具有特殊生理活性的有机硫天然产物和非天然硫化合物的全合成。将研究高活性小有机硫化合物的微波光谱。将合成作为配体和/或在材料科学中感兴趣的新多硫醇。 %%% 凭借这一续展奖，合成有机计划将支持纽约州立大学奥尔巴尼分校化学系 Eric Block 博士的研究，他将研究天然存在和合成的有机硫化合物。在天然产品领域，重点将放在高度不稳定的化合物上，这些化合物解释了包括大蒜和洋葱在内的葱属家族的气味和风味。在合成领域，有机硫化合物将用于生产可用于螯合重金属或合成新材料的新化合物。