Synthetic Organochalcogen Chemistry

合成有机硫属化学

• 批准号: 0744578
• 负责人: Eric Block
• 金额: $ 47.48万
• 依托单位: SUNY at Albany
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0744578&HistoricalAwards=false
• 关键词: Synthetic; Organochalcogen; Chemistry

This project will continue work on the chemistry of organic compounds of sulfur, selenium and tellurium, including development of an environmentally benign nematicide based on garlic oil, study of angiogenesis by compounds related to garlic-derived ajoene, chalcogen-containing molecular wires for use in nanotechnology, completion of the total syntheses of thiarubrine E (an antibiotic from Asteracea plants) and of lentinic acid (novel poly-sulfur compound from shiitake mushrooms), study of sequential one-electron oxidation of 1,5-dichalcogenacyclooctanes, and synthesis of thiacorrannulene and of trifluoromethylselenomethionine (a novel amino acid homologue). With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Eric Block of the Department of Chemistry at the University at Albany, SUNY. Professor Block's research efforts seek to advance knowledge and develop practical uses of organic compounds of the chalcogen elements (sulfur, selenium and tellurium). The proposed research will contribute to environmentally benign methods for agricultural pest control. Successful development of the proposed methodology will have an impact on agricultural industries. Other projects could lead to the development of new pharmaceuticals as well as new materials for use in nanotechnology.

该项目将继续研究硫、硒和碲的有机化合物的化学，包括开发基于大蒜油的环境友好型杀线虫剂，研究大蒜衍生的阿焦烯化合物的血管生成，用于纳米技术的含硫分子线，完成了硫代红菌素E的全合成（一种从菊科植物中提取的抗生素）和lentinic acid（来自香菇的新型多硫化合物），1，5-二硫代环辛烷的顺序单电子氧化的研究，和三氟甲基硒代甲硫氨酸（一种新的氨基酸同系物）的合成。有了这个奖项，有机和高分子化学计划是支持教授埃里克块的化学系在奥尔巴尼，纽约州立大学的研究。 布洛克教授的研究工作旨在促进知识和开发硫族元素（硫，硒和碲）的有机化合物的实际用途。拟议的研究将有助于环境友好的农业害虫控制方法。拟议方法的成功制定将对农业产生影响。其他项目可能导致开发新的药物以及用于纳米技术的新材料。