Synthetic Organochalcogen Chemistry

该项目将继续开展硫、硒和碲有机化合物化学方面的工作，包括开发一种基于大蒜油的环境友好型杀线虫剂、研究与大蒜提取的ajoene相关的化合物的血管生成、用于纳米技术的含硫分子导线、完成硫代芦荟素E(一种来自菊科植物的抗生素)和香菇酸(从香菇中提取的新型多硫化合物)的全合成、1，5-二卤代环辛烷的顺序单电子氧化研究、硫代环烯丙烷和三氟甲基硒蛋氨酸(一种新型氨基酸同系物)的合成。通过这一奖项，有机和高分子化学项目支持纽约州立大学奥尔巴尼分校化学系埃里克·布洛克教授的研究。布洛克教授的研究工作旨在增进硫族元素有机化合物(硫、硒和碲)的知识并开发其实际用途。这项拟议的研究将有助于开发环境友好的农业病虫害防治方法。拟议方法的成功开发将对农业产生影响。其他项目可能导致开发新的药物以及用于纳米技术的新材料。

This project will continue work on the chemistry of organic compounds of sulfur, selenium and tellurium, including development of an environmentally benign nematicide based on garlic oil, study of angiogenesis by compounds related to garlic-derived ajoene, chalcogen-containing molecular wires for use in nanotechnology, completion of the total syntheses of thiarubrine E (an antibiotic from Asteracea plants) and of lentinic acid (novel poly-sulfur compound from shiitake mushrooms), study of sequential one-electron oxidation of 1,5-dichalcogenacyclooctanes, and synthesis of thiacorrannulene and of trifluoromethylselenomethionine (a novel amino acid homologue). With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Eric Block of the Department of Chemistry at the University at Albany, SUNY. Professor Block's research efforts seek to advance knowledge and develop practical uses of organic compounds of the chalcogen elements (sulfur, selenium and tellurium). The proposed research will contribute to environmentally benign methods for agricultural pest control. Successful development of the proposed methodology will have an impact on agricultural industries. Other projects could lead to the development of new pharmaceuticals as well as new materials for use in nanotechnology.