Synthetic Organosulfur and Organoselenium Chemistry

合成有机硫和有机硒化学

• 批准号: 0450505
• 负责人: Eric Block
• 金额: $ 48.66万
• 依托单位: SUNY at Albany
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-15 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0450505&HistoricalAwards=false
• 关键词: Synthetic; Organosulfur; Organoselenium; Chemistry

The focus of this research involves nine goals. Major aspects include: 1) synthesis of new, mixed selenium-, silicon-, sulfur-and tin-containing 4-6- and 8-10-membered rings; 2) synthesis of bicyclic 1,2-dichalcogenins; 3) sulfur-containing mouse semiochemicals, new (mercaptomethyl)silanes, and artifact formation with SPME fibers; 4) total synthesis of lentinic acid from shiitake mushrooms; 5) synthesis of biologically relevant 1,2-diselenolanes; 6) synthesis of 5-heterobicyclo[1.1.1]pentanes and 2-thiabicyclo-[1.1.0]butanes; 7) synthesis of selenium analogues of biologically active organosulfur compounds; 8) microwave characterization of small organoselenium compounds; 9) Allium chemistry: synthesis of optically active ajoene and S-2-fluoro-2-propenylthio derivatives. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Eric Block in the Department of Chemistry at SUNY at Albany. Professor Block will focus his work on seeking to answer fundamental questions relating to the chemistry of the elements sulfur and selenium, important constituents of biological systems. The project has broader impact in the pharmaceutical industry and in the area of human health. Further, the project is an excellent venue for the training of undergraduates, graduate students and postdoctoral colleagues.

这项研究的重点涉及九个目标。主要内容包括：1)合成新的含硒、含硅、含硫、含锡的4-6-和8-10元环；2)合成双环1，2-二盐基元；3)含硫小鼠信息化合物、新的(硫甲基)硅烷以及利用SPME纤维形成人工制品；4)香菇全合成香菇酸；5)合成与生物相关的1，2-二硒戊烷；6)合成5-杂双环[1.1.1]戊烷和2-硫杂双环[1.1.0]丁烷；7)合成具有生物活性的有机硫化合物的硒类似物；8)小分子有机硒化合物的微波表征；9)葱化学：合成光学活性的阿霍烯和S-2-氟-2-丙烯硫代衍生物。通过这一奖项，有机和高分子化学项目支持艾瑞克·布洛克博士在纽约州立大学奥尔巴尼分校化学系的研究。布洛克教授将把工作重点放在寻求回答与硫和硒元素的化学有关的基本问题上，硫和硒是生物系统的重要组成部分。该项目在制药业和人类健康领域具有更广泛的影响。此外，该项目也是培养本科生、研究生和博士后同事的绝佳场所。