Designer Paths for Guided Axon Extension in Three- Dimensional Structures

三维结构中引导轴突延伸的设计路径

• 批准号: 9805835
• 负责人: Wei-Shou Hu
• 金额: $ 32.16万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 2002-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9805835&HistoricalAwards=false
• 关键词: Designer; Paths; Guided; Axon; Extension

9805835 Hu The long-term objective of this project is to develop a method of directing nerve axonal growth within three-dimensional matrices for tissue engineering applications. To facilitate the selective deposition of biologically active molecules in a three-dimensional structure, a photochemical technique will be employed that relies on a penetrating laser to spatially control the binding of bioactive molecules. This method can be applied to deposit virtually any molecule that can be conjugated to a photolinker. The immediate objective of this project is to apply the developed method to investigate the factors critical to path finding in both two-dimensional surfaces and three-dimensional structures. ***

9805835 Hu该项目的长期目标是开发一种用于组织工程应用的在三维基质内引导神经轴突生长的方法。 为了促进生物活性分子在三维结构中的选择性沉积，将采用光化学技术，该技术依赖于穿透激光来空间控制生物活性分子的结合。 该方法可应用于存款几乎任何可与光连接体缀合的分子。 该项目的直接目标是应用所开发的方法来研究在二维表面和三维结构中路径查找的关键因素。 ***