Replacement of Console and Reverse-Detection Probe for XL-300 NMR Spectrometer

9319666阿克曼化学研究仪器和设施计划的这一奖项将帮助华盛顿大学化学系为现有的300兆赫兹多核核磁共振光谱仪购买现代化的更换控制台和反向探测探头。该设备将用于下列领域的研究：(1)合成核酶、水解化学核酸酶和用于控制基因表达的催化反义试剂；(2)扩展有机化学和高活性中间体的研究、快速反应的前沿轨道控制、锗的气相重排、合成锡烯的新路线以及三线态硅烯、锗和锡烯的分子设计；(3)芳香族金属环的合成和活性；以及(4)液相材料加工。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱是必不可少的。

9319666 Ackerman This award from the Chemistry Research Instrumentation and Facilities Program will assist the Department of Chemistry at Washington University in the purchase of a modern replacement console and reverse-detection probe for an existing 300 MHz multinuclear NMR Spectrometer. This equipment will be used in the following areas of research: (1) Synthetic Ribozymes, Hydrolytic Chemical Nucleases, and Catalytic Antisense Agents for the Control of Gene Expression; (2) Extended Organic Chemistry and the Study of Highly Reactive Intermediates, Frontier Orbital Control of Very Fast Reactions, Gas-Phase Rearrangements of Germylenes, New Routes to Stannylenes, and the Molecular Design of Triplet Silylenes, Germylenes, and Stannylenes; (3) Synthesis and Reactivity of Aromatic Metallacycles; and (4) Solution-Phase Materials Processing. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research.