Acquisition of an 800 MHz NMR Spectrometer Console and Probes

请提供资金以获得Bruker Biospin核磁共振Avance NEO 800 MHz控制台和 相关部件，包括BMPC-2磁体控制系统、CryoPlatform/5、MASIII 气动控制单元，TCI-H&F三谐振低温探头，MAS三伽马1.9 mm固态 探头和MAS 3.2 mm固态CryoProbe，将安装在现有的Bruker Biospin 800 MHz上 核磁共振磁体系统。安装了本核磁共振Avance I控制台和TCI CryoProbe/1 2003和2004年，并被Bruker Biospin宣布于2018年达到服务终止(EOS) 和2019年。请求的检测提供了增强的灵敏度和功能 用于现代核磁共振实验，包括温度锁定、非均匀采样、复杂 波形产生、魔角旋转(MAS)固态核磁共振波谱和高级 用于溶液和固态MAS应用的低温探头设计。所请求的 仪器设备对纽约结构生物学中心的首要目标至关重要 (NYSBC)，由纽约州九家研究机构组成的联盟，以支持 NIH资助的光谱仪主要用户和次要用户的研究。进行的研究 800 MHz核磁共振波谱仪的范围从结构/功能的基础研究 生物分子，阐明发病机制，发现新的先导化合物 应用于医药领域。所请求的仪器将极大地增强容量 800兆赫核磁共振波谱仪进行这项研究。

Funding is requested to obtain a Bruker Biospin NMR AVANCE NEO 800 MHz Console and associated components, including BMPC-2 magnet control system, CryoPlatform/5, MASIII pneumatic control unit, TCI-H&F triple-resonance CryoProbe, MAS tri-gamma 1.9 mm solid-state probe, and MAS 3.2 mm solid-state CryoProbe, to be installed on an existing Bruker Biospin 800 MHz NMR magnet system. The present NMR AVANCE I console and TCI CryoProbe/1 were installed 2003 and 2004 and were declared by Bruker Biospin to have reached “End of Service” (EOS) in 2018 and 2019, respectively. The requested instrumentation provides enhanced sensitivity and capabilities for modern NMR experiments, including temperature-locking, non-uniform sampling, complex waveform generation, magic-angle spinning (MAS) solid-state NMR spectroscopy, and advanced cryogenic probe design for both solution and solid-state MAS applications. The requested instrumentation is essential to the over-riding purpose of the New York Structural Biology Center (NYSBC), a consortium of nine research institutions in New York State, to support the specific aims of the NIH-funded research of the major and minor users of the spectrometer. Research conducted on the 800 MHz NMR Spectrometer ranges from fundamental studies of structure/function of biomolecules, to elucidation of mechanisms of pathogenesis, to discovery of novel lead compounds to pharmaceutical applications. The requested instrumentation will dramatically enhance the capacity of the 800 MHz NMR spectrometer to conduct this research.