Dissertation Research: Genetic Variability and Interdemic Selection in Small Populations

小行星9321689 近交衰退可能是种群规模减少的最严重遗传后果之一。 本研究以赤拟谷盗为模式系统，在细分群体中进行减少近交衰退选择的实证研究。 它将涉及两个迁移计划，随机和差异，在一组15个近交系来自同一远交种群之间的比较。 在差别迁移方案中，迁移者将从遭受较少近亲繁殖衰退的谱系被送到遭受较多近亲繁殖衰退的谱系。 在随机迁移方案中，迁移率将是相同的，但迁移者将根据近交衰退的水平随机发送。 相对于随机迁移方案，差异迁移方案中近交衰退水平的显著降低将表明对选择的显著响应。% 这项研究的意义在于它深入了解了小的细分种群内部和之间的基因流动的定量方面，这是一个对基本种群和保护生物学具有相当重要意义的问题。

9321689 Goodnight Inbreeding depression is potentially one of the most serious genetic consequences of reduced population size. This research is an empirical study on selection for reduced inbreeding depression among a subdivided population, using Tribolium castaneum as the model system. It will involve a comparison of two migration schemes, random and differential, among a set of fifteen inbred lineages derived from the same outbred stock population. In the differential migration scheme, migrants will be sent from lineages suffering from less inbreeding depression to lineages suffering from more inbreeding depression. In the random migration scheme, the rate of migration will be the same but migrants will be sent at random with respect to levels of inbreeding depression. A significant response to selection will be evident by a significant decrease in the level of inbreeding depression in the differential migration scheme, relative to the random migration scheme.%%% The significance of the research lies in its insight into the quantitative aspects of gene flow within and between small, subdivided populations, an issue of considerable significance to basic population and conservation biology.***