Dissertation Research: Genetic Variability and Interdemic Selection in Small Populations

9321689晚安近亲繁殖衰退可能是种群数量减少最严重的遗传后果之一。本研究是以赤霉菌为模式系统，在细分种群中进行减少近交衰退选择的实证研究。它将涉及两种迁移方案的比较，随机和差异，在一组15个近交系派生自相同的近交系种群。在差别化移民计划中，移民将从近亲繁殖障碍较少的血统被送到近亲繁殖障碍较多的血统。在随机迁徙计划中，迁移率将是相同的，但迁徙将根据近亲繁殖衰退的水平随机发送。与随机迁徙方案相比，差异迁徙方案中近亲交配抑制的水平显著降低，这将是对选择的显著反应。%这项研究的意义在于它洞察了小而细分的种群内部和之间的基因流动的数量方面，这一问题对基础种群和保护生物学具有相当重要的意义。

9321689 Goodnight Inbreeding depression is potentially one of the most serious genetic consequences of reduced population size. This research is an empirical study on selection for reduced inbreeding depression among a subdivided population, using Tribolium castaneum as the model system. It will involve a comparison of two migration schemes, random and differential, among a set of fifteen inbred lineages derived from the same outbred stock population. In the differential migration scheme, migrants will be sent from lineages suffering from less inbreeding depression to lineages suffering from more inbreeding depression. In the random migration scheme, the rate of migration will be the same but migrants will be sent at random with respect to levels of inbreeding depression. A significant response to selection will be evident by a significant decrease in the level of inbreeding depression in the differential migration scheme, relative to the random migration scheme.%%% The significance of the research lies in its insight into the quantitative aspects of gene flow within and between small, subdivided populations, an issue of considerable significance to basic population and conservation biology.***