NMR Spectrometer for Chemical Catalysis Studies: Solid State Enzymes and Catalytic Porous Solids

用于化学催化研究的核磁共振波谱仪：固态酶和催化多孔固体

• 批准号: 9401986
• 负责人: Ann McDermott
• 金额: $ 15万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-05-15 至 1995-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9401986&HistoricalAwards=false
• 关键词: NMR; Spectrometer; Chemical; Catalysis; Studies

This award from the Chemistry Research Instrumentation and Facilities Program and the Instrument Development for Biological Research Program of the Division of Biological Instrumentation and Resources will help the Department of Chemistry at Columbia University acquire a 400 MHz Nuclear Magnetic Resonance spectrometer for solids investigations, which will be used in the following research projects: (1) hydrogen bonding and proton diffusion in hydrogen bonded systems; (2) catalysis using enzyme-transition state analog complexes and trapped catalytic intermediates; (3) the photochemistry, dynamics and chemical details of the binding modes in complexes of photoactive organic molecules on porous solids such as zeolites; (4) the molecular mechanism of the activatimn of rhodopsin by light; and (5) characterization of the interaction between the glutamate receptor and a highly specific inhibitor. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules

生物仪器与资源系化学研究仪器与设施计划和生物研究仪器开发计划的这一奖项将帮助哥伦比亚大学化学系获得一台用于固体研究的400 MHz核磁共振波谱仪，该仪器将用于下列研究项目：(1)氢键体系中的氢键和质子扩散；(2)利用酶-过渡态模拟化合物和捕获的催化中间体的催化；(3)光活性有机分子在沸石等多孔固体上结合模式的光化学、动力学和化学细节；(4)光激活视紫红质的分子机制；以及(5)谷氨酸受体与一种高特异性抑制剂之间相互作用的特征。核磁共振波谱是阐明分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究分子之间相互作用的动力学