NMR Spectrometer for Chemical Catalysis Studies: Solid State Enzymes and Catalytic Porous Solids

该奖项来自化学研究仪器和设施计划以及生物仪器和资源部生物研究计划的仪器开发，将帮助哥伦比亚大学化学系获得用于固体研究的400 MHz核磁共振光谱仪，该光谱仪将用于以下研究项目：（1）氢键和氢键系统中的质子扩散;（2）使用酶-过渡态类似物复合物和捕获的催化中间体的催化;（3）光活性有机分子在多孔固体如沸石上的复合物中的结合模式的光化学、动力学和化学细节;（4）光激活视紫红质的分子机制;（5）谷氨酸受体与高特异性抑制剂之间相互作用的表征。 核磁共振（NMR）光谱是解析分子结构的最有力的工具。 它用于识别未知物质，表征分子内原子的特定排列，并研究分子间相互作用的动力学

This award from the Chemistry Research Instrumentation and Facilities Program and the Instrument Development for Biological Research Program of the Division of Biological Instrumentation and Resources will help the Department of Chemistry at Columbia University acquire a 400 MHz Nuclear Magnetic Resonance spectrometer for solids investigations, which will be used in the following research projects: (1) hydrogen bonding and proton diffusion in hydrogen bonded systems; (2) catalysis using enzyme-transition state analog complexes and trapped catalytic intermediates; (3) the photochemistry, dynamics and chemical details of the binding modes in complexes of photoactive organic molecules on porous solids such as zeolites; (4) the molecular mechanism of the activatimn of rhodopsin by light; and (5) characterization of the interaction between the glutamate receptor and a highly specific inhibitor. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules