MRI: Upgrade of a 400 MHz NMR Spectrometer to Support Research, Research Training, and Chemical Education

该奖项由主要研究仪器和化学研究仪器项目支持。来自索尔兹伯里大学的Jose Juncosa教授和他的同事Seth Friese升级了一台400兆赫核磁共振光谱仪的控制台，并为其配备了一个自动转换器，使学生能够收集多个样本的数据。总的来说，核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。该仪器对共同撰写论文并在地方和国家会议上展示其成果的学生研究人员产生了积极影响。光谱仪在其扩展中促进了更多的研究机会，并使后代在科学和工程方面获得了能力。核磁共振波谱仪对更广泛的地理区域，特别是德尔马瓦半岛下东岸的研究和研究培训活动的质量和生产力有直接影响。该光谱仪与马里兰大学东海岸的研究人员共享，这是一所毗邻的历史悠久的黑人学院和大学（HBCU）。该建议旨在加强各级的研究和教育。它特别有助于合成5-HT-24受体激动剂的表征和新的含氮供体配体的设计。该光谱仪用于表征恶唑盐转化合成的生物碱，并鉴定基因和酶。该仪器帮助研究人员开发可切换的磁共振成像造影剂，用于与MRI扫描设备结合使用，并用于分析合成的2-氧吡咯胺酮杂化类似物。核磁共振波谱仪还用于寻找生物活性微生物天然产物和混合抗氧化剂/毒蕈碱激动剂，这是一种激活某些神经元和其他细胞细胞膜中毒蕈碱乙酰胆碱受体活性的药物。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor Jose Juncosa from Salisbury University and colleague Seth Friese have upgraded the console of a 400 MHz NMR spectrometer and equipped the resulting spectrometer with an automatic changer that allows students to collect data on multiple samples. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The instrument positively impacts student researchers who coauthor papers and present their results at local and national conferences. The spectrometer promotes enhanced research opportunities in its outreach, and empowers future generations in science and engineering. The NMR spectrometer has a direct impact on the quality and productivity of research and research training activities in the broader geographic region, particularly the lower Eastern Shore of the Delmarva Peninsula. The spectrometer is shared with researchers at the University of Maryland Eastern Shore, a neighboring Historically Black College and University (HBCU).The proposal is aimed at enhancing research and education at all levels. It especially aids in the characterization of synthetic agonists for the serotonin receptor denominated 5-HT-24 and the design of new nitrogen-containing donor ligands. The spectrometer is used to characterize alkaloids synthesized using oxazolium salt transformations and to identify genes and enzymes. The instrument helps researchers developing switchable magnetic resonance imaging contrast agents used in conjunction with MRI scanning devices and for the analysis of synthetic 2-oxopyrroline enaminone hybrid analogues. The NMR spectrometer is also utilized on the search for bioactive microbial natural products and for hybrid antioxidants/muscarinic agonists which are agents that activates the activity of the muscarinic acetylcholine receptor in cell membranes of certain neurons and other cells.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.