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MRI: Upgrade of a 400 MHz NMR Spectrometer to Support Research, Research Training, and Chemical Education

MRI：升级 400 MHz NMR 波谱仪以支持研究、研究培训和化学教育

基本信息

批准号：
1827905
负责人：
Jose Juncosa
金额：
$ 26.52万
依托单位：
Salisbury University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2021-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1827905&HistoricalAwards=false
关键词：
MRI Upgrade 400 MHz NMR

项目摘要

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor Jose Juncosa from Salisbury University and colleague Seth Friese have upgraded the console of a 400 MHz NMR spectrometer and equipped the resulting spectrometer with an automatic changer that allows students to collect data on multiple samples. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The instrument positively impacts student researchers who coauthor papers and present their results at local and national conferences. The spectrometer promotes enhanced research opportunities in its outreach, and empowers future generations in science and engineering. The NMR spectrometer has a direct impact on the quality and productivity of research and research training activities in the broader geographic region, particularly the lower Eastern Shore of the Delmarva Peninsula. The spectrometer is shared with researchers at the University of Maryland Eastern Shore, a neighboring Historically Black College and University (HBCU).The proposal is aimed at enhancing research and education at all levels. It especially aids in the characterization of synthetic agonists for the serotonin receptor denominated 5-HT-24 and the design of new nitrogen-containing donor ligands. The spectrometer is used to characterize alkaloids synthesized using oxazolium salt transformations and to identify genes and enzymes. The instrument helps researchers developing switchable magnetic resonance imaging contrast agents used in conjunction with MRI scanning devices and for the analysis of synthetic 2-oxopyrroline enaminone hybrid analogues. The NMR spectrometer is also utilized on the search for bioactive microbial natural products and for hybrid antioxidants/muscarinic agonists which are agents that activates the activity of the muscarinic acetylcholine receptor in cell membranes of certain neurons and other cells.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器项目支持。索尔兹伯里大学的 Jose Juncosa 教授和同事 Seth Friese 升级了 400 MHz NMR 波谱仪的控制台，并为最终的波谱仪配备了自动更换器，使学生能够收集多个样品的数据。一般来说，核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于进行前沿研究的化学家来说，使用最先进的核磁共振波谱仪至关重要。该工具对共同撰写论文并在地方和国家会议上展示其结果的学生研究人员产生积极影响。该光谱仪在其推广范围内促进了更多的研究机会，并增强了子孙后代在科学和工程方面的能力。核磁共振波谱仪对更广泛地理区域（特别是德尔马瓦半岛下东岸）的研究和研究培训活动的质量和生产力产生直接影响。该光谱仪与邻近的历史黑人学院和大学 (HBCU) 马里兰大学东岸分校的研究人员共享。该提案旨在加强各个层面的研究和教育。它特别有助于表征名为 5-HT-24 的血清素受体的合成激动剂以及新的含氮供体配体的设计。该光谱仪用于表征使用恶唑鎓盐转化合成的生物碱并鉴定基因和酶。该仪器帮助研究人员开发可切换的磁共振成像造影剂，与 MRI 扫描设备结合使用，并用于分析合成的 2-氧代吡咯啉烯胺酮混合类似物。核磁共振波谱仪还用于寻找生物活性微生物天然产物和混合抗氧化剂/毒蕈碱激动剂，这些激动剂是激活某些神经元和其他细胞细胞膜中毒蕈碱乙酰胆碱受体活性的药物。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和技术进行评估，被认为值得支持。更广泛的影响审查标准。