A 500MHz NMR Spectrometer to Underpin Chemical Research at Bristol (invited resubmission)

这项建议涉及购买和安装科学硬件，这对布里斯托尔大学长期分析化学问题至关重要。核磁共振光谱学是现代化学分析几乎所有方面的基础技术——从生物到材料再到合成研究。它可以解释化学样品的组成、结构和运动，从而对这些纳米级系统中的分子特征有一个基本的了解。例如，化学学院将该技术应用于分析从天然来源分离的复杂生物活性化合物、制药和石化工业感兴趣的产品、与纳米科学、生物技术相关的新材料、监测复杂化学反应、阐明化学合成和复杂化学催化中产生的新结构。为了实现这些目标，核磁共振波谱支撑了250多名研究工作者的工作，并与一系列学术和工业应用建立了国内和国际联系。布里斯托尔大学化学学院的核磁共振设备目前使用了5台仪器，从7-23年不等，分辨率为270-400MHz，用于进行化学分析。学院开展的高水平研究日益增长的需求要求获得>400MHz领域的分辨率和灵敏度。提案中要求的新工具将促进许多领域的新前沿发展，并确保对学院当前研究水平的支持。新的500 MHz机器将使代谢产物、催化剂机制、天然产物结构、功能聚合物、蛋白质动力学、离子传感器和一系列其他材料的研究达到微克水平，这是迄今为止学校的研究人员无法达到的。

This proposal is concerned with the purchase and installation of scientific hardware that will be essential to the long term analysis of chemical problems at the University of Bristol. NMR spectroscopy is a technique that underpins nearly all apects of modern chemical analysis - from biological through materials to synthetic studies. It allows the elucidation of composition, structure and motion in chemical samples, leading to a fundamental understanding of molecular characteristics in these nano-scale systems. For example the School of Chemistry applies this technique to analysis of complex biologically active compounds isolated from natural sources, products of interest to the pharmaceutical and petrochemical industries, new materials relevant to nanoscience, biotechnology, monitoring complex chemical reactions, elucidation of novel structures produced in chemical synthesis and complex chemical catalysis. To these ends, NMR spectroscopy underpins the work of over 250 research workers, with national and international links to a range of academic and industrial applications. The NMR Facility within the School of Chemistry at Bristol University currently employs 5 instruments ranging from 7-23 years old with resolutions of 270-400MHz to conduct such chemical analysis. The increasing requirements of the high-level research undertaken in the School demand access to resolutions and sensitivity from fields >400MHz.The new instrument requested in the proposal will facilitate new and cutting edge developments in a number of areas as well as ensuring support for current levels of research in the School.The new 500 MHz machine will enable the study of of metabolic products, catalyst mechanisms, natural product structures, functional polymers, protein dynamics, ion-sensors and an array of other materials at down to microgram levels which hitherto have been inaccessible to the researchers in the School.