A 500MHz NMR Spectrometer to Underpin Chemical Research at Bristol (invited resubmission)

该提案涉及购买和安装科学硬件，这对布里斯托大学长期分析化学问题至关重要。NMR光谱是一种支持现代化学分析几乎所有方面的技术-从生物材料到合成研究。它可以阐明化学样品的组成、结构和运动，从而对这些纳米尺度系统的分子特征有了基本的了解。例如，化学学院将这种技术应用于分析从天然来源分离的复杂生物活性化合物，制药和石化行业感兴趣的产品，与纳米科学，生物技术相关的新材料，监测复杂的化学反应，阐明化学合成和复杂化学催化中产生的新结构。为此，NMR光谱学支持了250多名研究人员的工作，并与一系列学术和工业应用建立了国家和国际联系。布里斯托大学化学学院内的核磁共振设施目前使用5台仪器进行这种化学分析，这些仪器的使用年限从7年到23年不等，分辨率为270- 400 MHz。在学校进行的高层次研究的要求越来越高，要求从> 400 MHz的领域获得分辨率和灵敏度。提案中要求的新仪器将促进许多领域的新的和前沿的发展，并确保支持学校目前的研究水平。新的500 MHz机器将能够研究代谢产物，催化剂机制，天然产物结构，功能性聚合物，蛋白质动力学，离子传感器和一系列其他材料，这些材料低至微克级，迄今为止学院的研究人员无法获得。

This proposal is concerned with the purchase and installation of scientific hardware that will be essential to the long term analysis of chemical problems at the University of Bristol. NMR spectroscopy is a technique that underpins nearly all apects of modern chemical analysis - from biological through materials to synthetic studies. It allows the elucidation of composition, structure and motion in chemical samples, leading to a fundamental understanding of molecular characteristics in these nano-scale systems. For example the School of Chemistry applies this technique to analysis of complex biologically active compounds isolated from natural sources, products of interest to the pharmaceutical and petrochemical industries, new materials relevant to nanoscience, biotechnology, monitoring complex chemical reactions, elucidation of novel structures produced in chemical synthesis and complex chemical catalysis. To these ends, NMR spectroscopy underpins the work of over 250 research workers, with national and international links to a range of academic and industrial applications. The NMR Facility within the School of Chemistry at Bristol University currently employs 5 instruments ranging from 7-23 years old with resolutions of 270-400MHz to conduct such chemical analysis. The increasing requirements of the high-level research undertaken in the School demand access to resolutions and sensitivity from fields >400MHz.The new instrument requested in the proposal will facilitate new and cutting edge developments in a number of areas as well as ensuring support for current levels of research in the School.The new 500 MHz machine will enable the study of of metabolic products, catalyst mechanisms, natural product structures, functional polymers, protein dynamics, ion-sensors and an array of other materials at down to microgram levels which hitherto have been inaccessible to the researchers in the School.