MRI: Acquisition of a 400 MHz NMR Spectrometer to Support Undergraduate Research and Chemical Education at Towson University

MRI：购买 400 MHz NMR 波谱仪以支持陶森大学的本科生研究和化学教育

• 批准号: 0923051
• 负责人: Clare Muhoro
• 金额: $ 30.73万
• 依托单位: Towson University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0923051&HistoricalAwards=false
• 关键词: MRI; Acquisition; 400; MHz; NMR

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research Instrumentation (MRI) program, Principal Investigators Clare Muhoro and Lev Ryzhkov and colleagues Timothy Brunker, Barry Margulies, Ana Maria Soto and Shannon Stitzel from Towson University will acquire a 400 MHz NMR spectrometer to support research and teaching at their institution. Their proposed research spans a number of areas in chemistry and biology, including: 1) the investigation of spiropyran-based molecularly imprinted polymer sensors; 2) the study of the binding of aminoglycoside antibiotics to RNA; 3) the synthesis, detection and quantitation of isotope-labeled acyclovair and its metabolites; 4) the study of the degradation of N-methylcarbamate pesticides under aquatic conditions; 5) the study of the lifetime of primary acyloxy radicals using CIDNP spectroscopy ; 6) the synthesis of coordination complex-based chiral molecular switches and 6) the synthesis, characterization and application of phosphanyl(organyl)boranes. The instrumentation will also be used in teaching and training of undergraduate and graduate students (MS) in coursework, as well as research at Towson. The spectrometer will play a critical role in preparing a diverse group of students for Maryland's technical and scientific workforce. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry and biochemistry, as well as in the training of a diverse group of students.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。通过这项来自主要研究仪器（MRI）项目的奖励，来自陶森大学的首席研究员Clare Muhoro和Lev Ryzhkov及其同事Timothy Brunker， Barry Margulies， Ana Maria Soto和Shannon Stitzel将获得一台400 MHz核磁共振光谱仪，以支持他们机构的研究和教学。他们提出的研究跨越了化学和生物学的许多领域，包括：1)基于螺吡喃的分子印迹聚合物传感器的研究；2)氨基糖苷类抗生素与RNA结合的研究；3)同位素标记的无环丁香苷及其代谢物的合成、检测和定量；4)水生条件下n -甲基氨基甲酸酯类农药的降解研究；5)利用CIDNP谱法研究伯氧基自由基的寿命；6)基于配位配合物的手性分子开关的合成；6)磷酰（有机基）硼烷的合成、表征及应用。该仪器也将用于教学和培训本科生和研究生（MS）的课程，以及研究在陶森。光谱仪将在为马里兰州的技术和科学劳动力培养多样化的学生群体方面发挥关键作用。核磁共振（NMR）波谱是化学家用来研究分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果将对合成有机/无机化学和生物化学以及对不同学生群体的培训产生影响。