MRI: Acquisition of a 400 MHz NMR Spectrometer to Support Undergraduate Research and Chemical Education at Towson University

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。有了这个来自主要研究仪器（MRI）计划的奖项，首席研究员克莱尔穆霍罗和列夫雷日科夫以及同事蒂莫西布伦克，巴里马古利斯，安娜玛丽亚索托和香农Stitzel从陶森大学将获得一个400 MHz的NMR光谱仪，以支持他们机构的研究和教学。 他们提出的研究跨越了化学和生物学的许多领域，包括： 1)研究了氨基糖苷类抗生素与RNA的结合，合成、检测和定量同位素标记的阿昔洛韦及其代谢产物，研究了N-甲基氨基甲酸酯类农药在水环境中的降解，研究了CIDNP光谱法测定伯酰氧基自由基的寿命，研究了氨基糖苷类抗生素在水环境中的降解机理。6）配位配合物型手性分子开关的合成; 6）膦基（有机基）硼烷的合成、表征及应用。 该仪器还将用于教学和培训本科生和研究生（MS）的课程，以及在陶森的研究。 光谱仪将发挥关键作用，为马里兰州的技术和科学劳动力准备一个多样化的学生群体。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学和生物化学以及对不同学生群体的培训产生影响。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research Instrumentation (MRI) program, Principal Investigators Clare Muhoro and Lev Ryzhkov and colleagues Timothy Brunker, Barry Margulies, Ana Maria Soto and Shannon Stitzel from Towson University will acquire a 400 MHz NMR spectrometer to support research and teaching at their institution. Their proposed research spans a number of areas in chemistry and biology, including: 1) the investigation of spiropyran-based molecularly imprinted polymer sensors; 2) the study of the binding of aminoglycoside antibiotics to RNA; 3) the synthesis, detection and quantitation of isotope-labeled acyclovair and its metabolites; 4) the study of the degradation of N-methylcarbamate pesticides under aquatic conditions; 5) the study of the lifetime of primary acyloxy radicals using CIDNP spectroscopy ; 6) the synthesis of coordination complex-based chiral molecular switches and 6) the synthesis, characterization and application of phosphanyl(organyl)boranes. The instrumentation will also be used in teaching and training of undergraduate and graduate students (MS) in coursework, as well as research at Towson. The spectrometer will play a critical role in preparing a diverse group of students for Maryland's technical and scientific workforce. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry and biochemistry, as well as in the training of a diverse group of students.