MRI: Acquisition of a 400 MHz NMR Spectrometer to Support Undergraduate Research and Chemical Education at Florida Gulf Coast University

凭借主要研究仪器计划 (MRI) 的奖励和化学研究仪器计划 (CRIF) 的支持，佛罗里达海湾海岸大学将购买一台 400 MHz NMR 波谱仪。该仪器将允许在有机合成和材料、肽、法医和无机化学等不同领域进行研究，并加强大学的教学计划。该研究将影响生物和环境领域，包括 DNA 稳定性、抗病毒肽、新药前体和气体吸附材料。一般来说，核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于进行前沿研究的化学家来说，使用最先进的核磁共振波谱仪至关重要。该仪器将成为佛罗里达海湾海岸大学本科生教学和研究的一个组成部分。 NMR 还将提高化学部门与当地执法机构以及当地生物技术公司在药物鉴定方面合作的能力。该提案旨在加强各级的研究和教育，特别是在合成（a）仿生离子液体等领域； (b) 药用相关天然产物； (c) 生物活性分子； (d) 研究膜破坏性抗病毒肽的结构和功能； (e) 研究 NMR 的法医应用，重点关注 DNA 的长期结构和化学稳定性； (f) 研究带柱离散结构的金属有机材料。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Florida Gulf Coast University will acquire a 400 MHz NMR spectrometer. The instrument will allow research in different areas including organic synthesis and materials, peptide, forensic and inorganic chemistry and enhance the teaching program at the University. The research will impact areas of biological and environmental interest including DNA stability, anti-viral peptides, precursors to novel drugs and gas adsorption materials. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument will be an integral part of teaching as well as research performed by undergraduate students at Florida Gulf Coast University. The NMR will also increase the chemistry department's capability to collaborate with local law enforcement institutions on drug identification as well as with local bio-tech companies.The proposal is aimed at enhancing research and education at all levels, especially in areas such as synthesizing (a) bio-inspired ionic liquids; (b) medicinally relevant natural products; (c) bioactive molecules; (d) studying structure and function of membrane disruptive anti-viral peptides; (e) studying forensic applications of NMR with concentration in long-term structural and chemical stability of DNA; and (f) studying metal-organic materials from pillared discrete structures.