A Hybrid Rotor for Continuous Field-Flow Fractionation

CTS-9406702华盛顿州立大学科尼利厄斯F。象牙理查德湖佐拉斯 摘要 本研究针对连续场流分馏（FFF）混合转子的发展。 通过在二维系统中将常规沉降与FFF相结合，原则上可以设计出选择性与离心场的平方成比例的转子。 然而，流动不稳定的问题阻碍了转子的发展。 研究的主要目的是确定转子是否可以在没有离心不稳定性的情况下运行。 线性稳定性理论将用于确定在适当的实验参数方面的不稳定性开始的条件。 如果成功的话，使用FFF将亚微米颗粒大规模分级至高纯度将变得实用。 这将对亚微米颗粒的分离技术产生强烈影响，特别是对于生物加工应用。

CTS-9406702 Washington State University Cornelius F. Ivory Richard L. Zollars ABSTRACT The research deals with the development of a hybrid rotor for continuous field-flow fractionation (FFF). By combining conventional sedimentation with FFF in a two-dimensional system, a rotor whose selectivity is proportional to the square of the centrifugal field can be designed in principle. However, problems with flow instability have hindered the rotor development. The primary objective of the research is to establish whether the rotor can be operated without centrifugal instability. Linear stability theory will be used to determine the conditions for the onset of instability in terms of appropriate experimental parameters. If successful, large scale fractionation of submicron particles to high purity will become practical using FFF. This would then have a strong impact on separations technology for submicron particles, especially for bioprocessing applications.