A Hybrid Rotor for Continuous Field-Flow Fractionation

CTS-9406702华盛顿州立大学科尼利厄斯·F·象牙·理查德·L·佐拉斯摘要本研究涉及用于连续场流分馏的混合式转子的开发。通过在二维系统中将常规沉淀法与FFF相结合，原则上可以设计出选择性与离心场的平方成正比的转子。然而，流动不稳定性问题阻碍了旋翼的发展。这项研究的主要目标是确定转子是否可以在没有离心力不稳定的情况下运行。线性稳定性理论将被用来根据适当的实验参数来确定失稳开始的条件。如果成功，使用FFF将使大规模的亚微米级颗粒分级达到高纯度成为现实。这将对亚微米颗粒的分离技术产生重大影响，特别是对生物处理应用。

CTS-9406702 Washington State University Cornelius F. Ivory Richard L. Zollars ABSTRACT The research deals with the development of a hybrid rotor for continuous field-flow fractionation (FFF). By combining conventional sedimentation with FFF in a two-dimensional system, a rotor whose selectivity is proportional to the square of the centrifugal field can be designed in principle. However, problems with flow instability have hindered the rotor development. The primary objective of the research is to establish whether the rotor can be operated without centrifugal instability. Linear stability theory will be used to determine the conditions for the onset of instability in terms of appropriate experimental parameters. If successful, large scale fractionation of submicron particles to high purity will become practical using FFF. This would then have a strong impact on separations technology for submicron particles, especially for bioprocessing applications.