A Hybrid Rotor for Continuous Field-Flow Fractionation

摘要本研究涉及用于连续场流分馏（FFF）的混合转子的开发。在二维系统中，将常规沉降与FFF相结合，原则上可以设计出选择性与离心场的平方成正比的转子。然而，流动不稳定性问题阻碍了转子的发展。研究的主要目的是确定转子是否可以在无离心失稳的情况下运行。线性稳定性理论将被用来确定在适当的实验参数的条件下开始的不稳定性。如果成功，利用FFF将亚微米颗粒大规模分离到高纯度将成为现实。这将对亚微米颗粒的分离技术，特别是生物处理应用产生强烈影响。

CTS-9406702 Washington State University Cornelius F. Ivory Richard L. Zollars ABSTRACT The research deals with the development of a hybrid rotor for continuous field-flow fractionation (FFF). By combining conventional sedimentation with FFF in a two-dimensional system, a rotor whose selectivity is proportional to the square of the centrifugal field can be designed in principle. However, problems with flow instability have hindered the rotor development. The primary objective of the research is to establish whether the rotor can be operated without centrifugal instability. Linear stability theory will be used to determine the conditions for the onset of instability in terms of appropriate experimental parameters. If successful, large scale fractionation of submicron particles to high purity will become practical using FFF. This would then have a strong impact on separations technology for submicron particles, especially for bioprocessing applications.