Environmentally Benign Chemical Synthesis and Processing Using New Ionic and Radical Organocobalt Reactions

利用新型离子和自由基有机钴反应进行环境友好的化学合成和加工

• 批准号: 9423782
• 负责人: Bruce Branchaud
• 金额: $ 26.95万
• 依托单位: University of Oregon Eugene
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-05-01 至 1998-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9423782&HistoricalAwards=false
• 关键词: Environmentally; Benign; Chemical; Synthesis; Processing

The focus of this research is the development of the ionic chemistry of cobaloxime pi-cations. Tandem sequences of cobaloxime-mediated ionic and cobaloxime-mediated radical reactions will afford methodology for the enantiospecific formation of carbon-oxygen, carbon-nitrogen and carbon-carbon bonds. The reaction chemistry will be used to develop new strategies for the synthesis of polyether antibiotics and D-aminosugars. The chemistry outlined is carried out in aqueous or biodegradable alcohol solvents with the production of metal residues that can be sequestered. Thus, the chemistry described will have an impact on the development of environmentally benign synthetic methodology. With this award, the Synthetic Organic Program is supporting the research of Dr. Bruce P. Branchaud of the Department of Chemistry at the University of Oregon. Professor Branchaud will focus his work on the development of environmentally benign synthetic methodology based on organocobalt chemistry. New strategies for the preparation of organic compounds possessing interesting biological properties will be developed.

本研究的重点是钴肟型阳离子离子化学的研究进展。钴肟介导的离子和钴肟介导的自由基反应的串联序列将为碳-氧、碳-氮和碳-碳键的对映专一性形成提供方法学。反应化学将被用于开发合成聚醚抗生素和D-氨基糖的新策略。概述的化学是在水或可生物降解的酒精溶剂中进行的，并产生可隔离的金属残留物。因此，所描述的化学将对环境友好的合成方法的发展产生影响。通过这个奖项，合成有机计划支持俄勒冈大学化学系的Bruce P.Branchaud博士的研究。Branchaud教授将专注于基于有机钴化学的环境友好合成方法的开发。将开发新的策略来制备具有有趣生物学特性的有机化合物。