Environmentally Benign Chemical Synthesis and Processing Using New Ionic and Radical Organocobalt Reactions

本研究的重点是钴胺酸盐离子化学的发展。钴胺肟介导的离子和钴胺肟介导的自由基反应的串联序列将为碳氧、碳氮和碳碳键的对映特异性形成提供方法。反应化学将用于开发合成聚醚类抗生素和d -氨基糖的新策略。概述的化学是在水或可生物降解的酒精溶剂中进行的，产生可以隔离的金属残留物。因此，所描述的化学将对环境友好的合成方法的发展产生影响。通过这个奖项，合成有机项目支持了俄勒冈大学化学系的Bruce P. Branchaud博士的研究。Branchaud教授将专注于开发基于有机钴化学的环保合成方法。制备具有有趣生物学特性的有机化合物的新策略将得到发展。

The focus of this research is the development of the ionic chemistry of cobaloxime pi-cations. Tandem sequences of cobaloxime-mediated ionic and cobaloxime-mediated radical reactions will afford methodology for the enantiospecific formation of carbon-oxygen, carbon-nitrogen and carbon-carbon bonds. The reaction chemistry will be used to develop new strategies for the synthesis of polyether antibiotics and D-aminosugars. The chemistry outlined is carried out in aqueous or biodegradable alcohol solvents with the production of metal residues that can be sequestered. Thus, the chemistry described will have an impact on the development of environmentally benign synthetic methodology. With this award, the Synthetic Organic Program is supporting the research of Dr. Bruce P. Branchaud of the Department of Chemistry at the University of Oregon. Professor Branchaud will focus his work on the development of environmentally benign synthetic methodology based on organocobalt chemistry. New strategies for the preparation of organic compounds possessing interesting biological properties will be developed.