Environmentally Benign Chemical Synthesis and Processing Using New Ionic and Radical Organocobalt Reactions

本研究的重点是离子化学的发展， 钴肟π-阳离子。 钴胺素介导的离子型和 钴肟介导的自由基反应将提供方法， 碳-氧、碳-氮和 碳碳键 反应化学将用于开发新的 聚醚类抗生素和D-氨基糖的合成策略。 所概述的化学反应是在含水或可生物降解的醇中进行的 溶剂与生产的金属残留物，可以螯合。 因此，所描述的化学将对以下方面的发展产生影响： 环境友好的合成方法。 有了这个奖项，合成有机计划正在支持这项研究 化学系的布鲁斯·P·布兰肖博士在 俄勒冈州大学。 Branchaud教授将把他的工作重点放在 开发环境友好的合成方法， 有机钴化学 有机合成的新策略 将开发具有令人感兴趣的生物学性质的化合物。

The focus of this research is the development of the ionic chemistry of cobaloxime pi-cations. Tandem sequences of cobaloxime-mediated ionic and cobaloxime-mediated radical reactions will afford methodology for the enantiospecific formation of carbon-oxygen, carbon-nitrogen and carbon-carbon bonds. The reaction chemistry will be used to develop new strategies for the synthesis of polyether antibiotics and D-aminosugars. The chemistry outlined is carried out in aqueous or biodegradable alcohol solvents with the production of metal residues that can be sequestered. Thus, the chemistry described will have an impact on the development of environmentally benign synthetic methodology. With this award, the Synthetic Organic Program is supporting the research of Dr. Bruce P. Branchaud of the Department of Chemistry at the University of Oregon. Professor Branchaud will focus his work on the development of environmentally benign synthetic methodology based on organocobalt chemistry. New strategies for the preparation of organic compounds possessing interesting biological properties will be developed.