U.S.-Hungry Research on Molecular and Genetic Analysis of Drosophila GAGA Factor Protein

小行星9507794 这个美国-普林斯顿大学的Paul Schedl博士和匈牙利生物研究中心的Janos Gausz博士和Henrik Gyurokovics博士之间的匈牙利研究项目将解决果蝇蛋白GAGA，该蛋白似乎在产生可访问的无核小体染色质区域中发挥关键作用。 这种蛋白质在体内与染色质的结合被认为有助于特定基因的转录。 总之，研究人员打算描述果蝇基因突变的表型效应，称为GAGA因子。 他们将使用分子，遗传和发育方法的组合。 结果预计将产生新的基本信息的遗传层次的调节，在这种不完全理解的DNA结合蛋白。 该遗传生物学项目通过使美国和东欧的领先专家能够联合收割机互补人才并在相互感兴趣和有能力的领域汇集研究资源，实现了推进科学知识的计划目标。 ***

9507794 Schedl This U.S.-Hungary research project, between Dr. Paul Schedl of Princeton University and Drs. Janos Gausz and Henrik Gyurokovics of the Hungarian Biological Research Center, will address a Drosophila protein, GAGA, that appears to play a critical role in generating accessible, nucleosome free regions of chromatin. Binding of this protein to chromatin in vivo is thought to facilitate transcription of particular genes. Together, the researchers intend to characterize the phenotypic effects of mutations in this Drosophila gene, called the GAGA factor. They will use a combination of molecular, genetic and developmental approaches. Results are expected to yield new basic information on the genetic hierarchy of regulation in this incompletely understood type of DNA-binding protein. This project in genetic biology fulfills the program objective of advancing scientific knowledge by enabling leading experts in the United States and Eastern Europe to combine complementary talents and pool research resources in areas of strong mutual interest and competence. ***