U.S.-Hungry Research on Molecular and Genetic Analysis of Drosophila GAGA Factor Protein

美国饥饿研究果蝇 GAGA 因子蛋白的分子和遗传分析

• 批准号: 9507794
• 负责人: Paul Schedl
• 金额: $ 4.62万
• 依托单位: Princeton University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-15 至 1999-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9507794&HistoricalAwards=false
• 关键词: U.S.; Hungry; Research; Molecular; Genetic

9507794 Schedl This U.S.-Hungary research project, between Dr. Paul Schedl of Princeton University and Drs. Janos Gausz and Henrik Gyurokovics of the Hungarian Biological Research Center, will address a Drosophila protein, GAGA, that appears to play a critical role in generating accessible, nucleosome free regions of chromatin. Binding of this protein to chromatin in vivo is thought to facilitate transcription of particular genes. Together, the researchers intend to characterize the phenotypic effects of mutations in this Drosophila gene, called the GAGA factor. They will use a combination of molecular, genetic and developmental approaches. Results are expected to yield new basic information on the genetic hierarchy of regulation in this incompletely understood type of DNA-binding protein. This project in genetic biology fulfills the program objective of advancing scientific knowledge by enabling leading experts in the United States and Eastern Europe to combine complementary talents and pool research resources in areas of strong mutual interest and competence. ***

这个美国和匈牙利的研究项目，由普林斯顿大学的Paul Schedl博士和dr。匈牙利生物研究中心的Janos Gausz和Henrik Gyurokovics将研究果蝇的一种蛋白质，GAGA，它似乎在产生可接近的、无核小体的染色质区域中起着关键作用。这种蛋白在体内与染色质结合被认为可以促进特定基因的转录。研究人员打算共同描述这种果蝇基因突变的表型效应，这种基因被称为GAGA因子。他们将结合使用分子、遗传和发育方法。研究结果有望为这种不完全了解的dna结合蛋白的遗传调控层次提供新的基本信息。这个基因生物学项目通过使美国和东欧的顶尖专家在共同感兴趣和能力强的领域结合互补的人才和集中研究资源，实现了推进科学知识的计划目标。＊＊＊