The Design and Synthesis of Artificial Proton Channels

人工质子通道的设计与合成

• 批准号: 9510626
• 负责人: Karin Akerfeldt
• 金额: $ 1.8万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-15 至 1996-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9510626&HistoricalAwards=false
• 关键词: Design; Synthesis; Artificial; Proton; Channels

This RPG in the Organic Synthesis Program to Professor Akerfeldt of Rutgers University will be used to design and synthesize artificial proton channels. In this work the PI will prepare a number of specific peptide sequences which will self assemble in a membrane and in an electric field to form proton channels. These model assemblies may be characterized and used to correlate with natural and uncharacterized systems. The objective is to try several different peptide sequences to determine how they assemble into conducting pores. Proton or ion channels regulate the flux of ions across membrane barriers. This is critical for cell regulation, cellular communication and nerve transmission. The synthesis and characterization of models of these systems will provide basic knowledge for extrapolation to the natural systems which at present are too complicated to characterize.

这个RPG在有机合成计划的教授Akerfeldt的 罗格斯大学将用于设计和合成人工 质子通道在这项工作中，PI将准备一些具体的 将在膜中和在膜中自组装的肽序列， 电场形成质子通道。这些模型组件可以是 有特征的，用于与自然的和无特征的相关联 系统.目的是尝试几种不同的肽序列， 确定它们如何组装成导电孔。 质子或离子通道调节跨膜离子的通量 隔栏.这对细胞调节和细胞通讯至关重要 和神经传递。模型的合成和表征 这些系统将提供基本知识， 自然系统，目前太复杂的特点。