Acquisition of Equipment for Three Dimensional Organismal Reconstruction, Analysis and Modeling

购置三维生物体重建、分析和建模设备

• 批准号: 9512486
• 负责人: Robert Full
• 金额: $ 10万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-12-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9512486&HistoricalAwards=false
• 关键词: Acquisition; Equipment; Three; Dimensional; Organismal

From cells to populations, an organism's world is three dimensional and dynamic. Organismal analysis is on the verge of a revolution. Never in history has the equipment and computing power been sufficient to allow most organismal biologists to move rapidly and quantitatively from one level of organization to another. We are entering an era of Integration that is simply unprecedented. To this end, we propose the creation of a unique facility for organismal biologists which consists of equipment that will allow acquisition, analysis, presentation and world-wide exchange of three-dimensional (3D) structure, function and behavior. We request four major, state-of-the-art pieces of equipment in the present proposal: a 3D stereo-microscope ("real-time", large depth-of-field, resolution-enhanced), 3D laser digitizer (capable of whole organismal scans in 15 sec at 14,580 points/sec with 0.05 mm resolution), 3D high-speed imager (capable of capturing 58,000 split images in 5 sec directly into memory) and a graphics computer cluster to process, analyze and exchange the images and data. Projects greatly facilitated or made possible include: the neural basis for behavior, biomechanics of morphogensis, gut-chemical reactor modeling of digestion, 3D musculo skeletal modeling of tetrapods to the earliest hominids, 3D dynamic whole-body modeling of insect locomotion (which has provided biological inspiration toward the design of autonomous legged robots), dinosaur behavior and the fluid movements that affect organisms in the world's oceans. The proposed infrastructure equipment will promote: the utilization of approaches across disciplines, cross fertilization of ideas, the creation of new fields of investigation, new approaches for museum data collection and distribution, new collaborations with engineers, computer scientists and the private sector, and novel training of future organismal biologists.

从细胞到种群，生物体的世界是三维的、动态的。 有机体分析正处于一场革命的边缘。在历史上，设备和计算能力从来不足以让大多数有机体生物学家从一个组织层次快速地、定量地移动到另一个层次。我们正在进入一个前所未有的一体化时代。为此，我们建议为有机体生物学家创建一个独特的设施，该设施包括允许三维（3D）结构，功能和行为的采集，分析，演示和全球交流的设备。我们在本提案中要求提供四件主要的最先进设备：三维立体显微镜（“实时”、大景深、分辨率增强）、3D激光数字化仪（能够在15秒内以14，580点/秒的速度扫描整个生物体，分辨率为0.05 mm），3D高速成像仪（能够在5秒内捕获58，000个分割图像直接存入存储器）和图形计算机集群来处理、分析和交换图像和数据。得到极大便利或得以实施的项目包括：行为的神经基础，形态发生的生物力学，消化的肠道化学反应器建模，从四足动物到最早的原始人类的3D肌肉骨骼建模，昆虫运动的3D动态全身建模（这为自主腿式机器人的设计提供了生物学灵感），恐龙行为以及影响世界海洋生物的流体运动。拟议的基础设施设备将促进：跨学科方法的利用，思想的交叉施肥，新的调查领域的创建，博物馆数据收集和分发的新方法，与工程师，计算机科学家和私营部门的新合作，以及未来有机生物学家的新培训。