Acquisition of Biophysics Instrumentation for Core Facility
为核心设施购置生物物理仪器
基本信息
- 批准号:9512577
- 负责人:
- 金额:$ 44.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:1995
- 资助国家:美国
- 起止时间:1995-08-01 至 1999-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Funds are requested for 50% of the cost of creating the University of Wisconsin-Madison Facility for Biophysics Instrumentation. This campus facility would be part of a $30 million expansion of the Department of Biochemistry. The facility would house six major instruments for the study of the complexation, conformation, and structure of biological and other macromolecules. These instruments are a MicroCal isothermal titration calorimeter, Calorimetry Sciences differential scanning calorimeter, Beckman analytical ultracentrifuge, Aviv circular dichroism spectrometer, Nicolet Fourier transform infrared spectrometer, and Pharmacia surface plasmon resonance detector. In addition, an Instrumentation Specialist would be hired to provide technical assistance to students, staff, and faculty on the installation, use, and maintenance of the requested instruments. The six principal users of the requested instrumentation are faculty members who use biophysical methods to study biopolymers and their interactions. These faculty reside in four divisions of the university- -Biochemistry, Chemistry, Chemical Engineering, and Pharmacy. They have active collaborations, routinely share equipment and ideas, and participate in common training and degree programs. Together, they would manage the operations of the proposed core facility. The major users of the requested instruments would be the approximately 100 students and staff being trained in the laboratories of the primary users. In addition, the requested instruments would greatly enhance the research and training efforts of ten secondary users. The laboratories of all primary and secondary users are within two city blocks of the proposed facility. Further, it is envisioned that the usage and hence the impact of the facility would soon broaden well beyond the research groups of the primary and secondary users. The need for the requested instrumentation is extreme. Physical approaches to the analysis of biological systems depend heavily on instrumentation. Researchers at the University of Wisconsin-Madison now have the ability to produce biomolecules on a large scale, and to perform limited physical analyses on these molecules. Yet, no isothermal titration calorimeters, no differential scanning calorimeters, no analytical ultracentrifuges, and no surface plasmon resonance detectors exist on any campus of the University of Wisconsin. The Madison campus has two antiquated circular dichroism spectrometers and only three Fourier transform infrared spectrometers, each of which is inaccessible to the primary and secondary users. This proposal is intended to address this crippling lack of modern biophysical instrumentation.
资金要求为50%的成本,建立威斯康星大学麦迪逊分校的生物物理仪器设施。这个校园设施将是生物化学系3000万美元扩建项目的一部分。该设施将容纳六个主要仪器,用于研究生物和其他大分子的络合,构象和结构。 这些仪器是MicroCal等温滴定量热仪、Calorimetry Sciences差示扫描量热仪、Beckman分析超吸收仪、Aviv圆二色光谱仪、尼科莱傅里叶变换红外光谱仪和Pharmacia表面等离子体共振检测器。此外,将聘请一名仪器专家为学生,教职员工和教师提供有关所需仪器的安装,使用和维护的技术援助。 所要求的仪器的六个主要用户是使用生物物理方法研究生物聚合物及其相互作用的教师。这些教师居住在大学的四个部门-生物化学,化学,化学工程和药学。他们有积极的合作,定期分享设备和想法,并参加共同的培训和学位课程。他们将共同管理拟议的核心设施的运作。所要求的仪器的主要用户将是在主要用户实验室接受培训的大约100名学生和工作人员。此外,所要求的仪器将大大加强10个二级用户的研究和培训工作。所有一级和二级用户的实验室都在拟议设施的两个街区内。此外,预计该设施的使用及其影响将很快扩大,远远超出主要和次要用户的研究群体。 对所需仪器的需求是极端的。分析生物系统的物理方法在很大程度上依赖于仪器。威斯康星大学麦迪逊分校的研究人员现在有能力大规模生产生物分子,并对这些分子进行有限的物理分析。然而,在威斯康星州的任何一个校园里,都没有等温滴定量热仪、差示扫描量热仪、分析型超临界流体仪和表面等离子体共振检测器。 麦迪逊校区有两台过时的圆二色光谱仪,只有三台傅里叶变换红外光谱仪,每台都是初级用户和次级用户无法访问的。这项建议旨在解决现代生物物理仪器严重缺乏的问题。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Ronald Raines其他文献
Ronald Raines的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Ronald Raines', 18)}}的其他基金
International Collaboration in Chemistry: Electron Delocalization in Polypeptide Structure and Stability
国际化学合作:多肽结构和稳定性中的电子离域
- 批准号:
1124944 - 财政年份:2011
- 资助金额:
$ 44.24万 - 项目类别:
Standard Grant
U.S.-Germany Cooperative Research: Thermodynamic and Proteolytic Stability of Proteins Containing Non-Natural Modules
美德合作研究:含有非天然模块的蛋白质的热力学和蛋白水解稳定性
- 批准号:
0129163 - 财政年份:2002
- 资助金额:
$ 44.24万 - 项目类别:
Standard Grant
A Collaborative Proposal: Engineering Disulfide Formation Kinetics to Enhance Heterologous Secretions in Saccharomyces Cerevisiae
合作提案:改造二硫键形成动力学以增强酿酒酵母的异源分泌
- 批准号:
0120690 - 财政年份:2001
- 资助金额:
$ 44.24万 - 项目类别:
Continuing Grant
Engineering Disulfide Formation Kinetics to Enhance Heterologous Secretion in Saccharomyces Cerevisiae (Collaborative)
工程化二硫键形成动力学以增强酿酒酵母的异源分泌(合作)
- 批准号:
9604563 - 财政年份:1996
- 资助金额:
$ 44.24万 - 项目类别:
Continuing Grant
Presidential Young Investigator Awards
总统青年研究员奖
- 批准号:
9057203 - 财政年份:1990
- 资助金额:
$ 44.24万 - 项目类别:
Continuing Grant
相似海外基金
FORTIFY - From Molecular Physiology to Biophysics of the Glymphatic System: a Regulatory Role for Aquaporin-4
FORTIFY - 从类淋巴系统的分子生理学到生物物理学:Aquaporin-4 的调节作用
- 批准号:
EP/Y023684/1 - 财政年份:2024
- 资助金额:
$ 44.24万 - 项目类别:
Research Grant
The Biophysics of Mesoscale, Reversible, Biomolecular Assemblies
中尺度可逆生物分子组装的生物物理学
- 批准号:
EP/Y000501/1 - 财政年份:2024
- 资助金额:
$ 44.24万 - 项目类别:
Fellowship
Biophysics of the brain’s waste disposal system: Understanding why we sleep
大脑废物处理系统的生物物理学:了解我们为什么睡觉
- 批准号:
DP230101113 - 财政年份:2023
- 资助金额:
$ 44.24万 - 项目类别:
Discovery Projects
CAREER: Surfactant Proteins that Stabilize Biomolecular Condensates: From Biophysics to Biomaterials for Biomanufacturing
职业:稳定生物分子缩合物的表面活性剂蛋白:从生物物理学到生物制造的生物材料
- 批准号:
2238914 - 财政年份:2023
- 资助金额:
$ 44.24万 - 项目类别:
Continuing Grant
Biophysics of liquid droplets in bacteria
细菌中液滴的生物物理学
- 批准号:
2887560 - 财政年份:2023
- 资助金额:
$ 44.24万 - 项目类别:
Studentship
REU Site: A Summer Research Experience in Structural and Computational Biology and Biophysics
REU 网站:结构与计算生物学和生物物理学的夏季研究经历
- 批准号:
2150396 - 财政年份:2023
- 资助金额:
$ 44.24万 - 项目类别:
Continuing Grant
Targeted Infusion Project: Creation of a Biophysics minor program for STEM success
有针对性的输液项目:为 STEM 成功创建生物物理学辅修课程
- 批准号:
2306506 - 财政年份:2023
- 资助金额:
$ 44.24万 - 项目类别:
Standard Grant
Center: REU Site: Interdisciplinary Research Opportunities in Biophysics
中心:REU 地点:生物物理学的跨学科研究机会
- 批准号:
2242779 - 财政年份:2023
- 资助金额:
$ 44.24万 - 项目类别:
Standard Grant