New Synthetic Methods Based on Iron Catalysts

点击翻译按钮获取中文摘要

The following new iron-catalyzed or-mediated reactions were disclosed in this study :(1) generation and synthetic reactions of metallacycles from enynedioates and Grignard reagents,(2) synthesis of cyclobutenols via the tandem addition of Grignard reagents to enynedioates,(3) generation and intramolecular alkylation of ferracyclopropenes and-propanes,(4) transformation of 1. 6-adducts of 2, 4-alkadienoates and Grignard reagents into benzocycloheptenones,(5) 1, 6-addition of heteroaromatic Grignard reagents to 2, 4-alkadienoates,(6) 1, 6-addition of aryl Grignard reagents toα,β,γ,δ-unsaturated sulfones and its synthetic application,(7) 1, 6-addition of Grignard reagents to enynoates,(8) regioselective substitution of 4, 5-epoxy-2-alkenoates with Grignard reagents,(9) formal total synthesis of vitamin K by the repeated use of the preceding regioselective substitution of 4, 5-epoxy-2-alkenoates with Grignard reagents,(10) preparation of stereo-defined cyclopropanes via the reductive dimerization of 4, 5-epoxy-2-alkenamides, and(11) preparation of peroxyacetals via the C-H bond activation of unsaturated ethers.