Electrospray Mass Spectrometry Equipment for Chemical and Biochemical Research

用于化学和生化研究的电喷雾质谱设备

• 批准号: 9528147
• 负责人: Oren Anderson
• 金额: $ 7.07万
• 依托单位: Colorado State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-02-15 至 1997-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9528147&HistoricalAwards=false
• 关键词: Electrospray; Mass; Spectrometry; Equipment; Chemical

This award from the Chemistry Research Instrumentation and Facilities Program will help the Department of Chemistry at Colorado State University purchase an electrospray probe and associated liquid chromatography sample introduction accessories for a Fisons/VG Quattro-SQ mass spectrometer, which will be used in research. The research activity to be supported includes:(1) mechanisms of DNA crosslinking by the anti-tumor antibiotics, (2) mechanistic studies of nucleic acid damage, (3) the association between polyelectrolytes and lyotropic liquid crystals, (4) characterization of iridoid and other glycosides isolated from medicinal plants, (5) the synthesis and physical studies of so-called supramolecular assemblies, (6) identification of the fragile polychalcogenide anions in solution, and (7) the characterization and estimation of purity of fluorinated carborane anions. Mass Spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic and organometallic molecules. The addition of the technique of electrospray extends the range of MS to protein and nucleic acid molecular weights far beyond those accessible by any other technique. The use of electrospray ionization in combination with high resolution provides the latest techniques available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry.

该奖项由化学研究仪器和设施 该项目将帮助科罗拉多州立大学化学系 大学购买电喷雾探针和相关液体 用于Fisons/VG Quattro-SQ的色谱进样附件 质谱仪，将用于研究。 研究活动 支持的包括：（1）DNA交联的机制，由 抗肿瘤抗生素，（2）核酸损伤机制研究， (3)聚电解质与溶致液体缔合 晶体，（4）环烯醚萜和分离的其他糖苷的表征 从药用植物，（5）合成和物理研究 所谓的超分子组装体，（6）易碎品的鉴定 溶液中的多硫族阴离子，以及（7）表征和 氟化碳硼烷阴离子纯度的估算。 质谱（MS）是用于探测紧密结构的技术， 详细信息，并获得大量的分子组成， 有机、生物有机和有机金属分子。 的加入 电喷雾技术将质谱的范围扩展到蛋白质和核酸 酸的分子量远远超过那些可获得的任何其他 法 电喷雾离子化与高浓度离子化结合使用， 分辨率提供了质谱分析中可用的最新技术。 它为化学家提供了一个最强大的工具， 化合物的表征。 获得这种能力， 质谱分析法对于前沿研究的进行是必不可少的 在许多化学领域。