NMR Console Upgrades

化学研究仪器和设施计划的这一奖项将帮助科罗拉多州立大学化学系获得两个最先进的NMR控制台，以升级现有的300 MHz NMR光谱仪，并改造AC控制台，以升级IBM WP-270 MHz NMR。该设备将加强以下领域的研究：（1）辅酶B12依赖性核糖核苷酸还原酶的金属生物化学，（2）合成修饰寡核苷酸的方法学开发，（3）非天然核苷的合成。 基于环丁烯酮化学的类似物，（4）甲脒和其它手性碳负离子，（5）高度氟化的弱配位阴离子的合成和应用，（6）DNA裂解的奎奴卡因机制和（7）钒和磷的生物有机和生物无机化学。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱分析技术是必不可少的。这些NMR研究的结果在聚合物、催化和生物学等领域都很有用。

This award from the Chemistry Research Instrumentation and Facilities Program will assist the Department of Chemistry at Colorado State University to acquire two state-of-the-art NMR consoles to upgrade existing 300 MHz NMR Spectrometers and retrofit the AC consoles to upgrade the IBM WP-270 MHz NMR. This equipment will enhance research in a number of areas including the following: (1) metallobiochemistry of co-enzyme B12-dependent ribonucleotide reductase, (2) development of methodology for synthesis of modified oligonucleotides, (3) synthesis of unnatural nucleoside analogs based on cyclobutenone chemistry, (4) formamidines and other chiral carbanions, (5) synthesis and application of highly fluorinated weakly coordinating anions, (6) quinocarcin mechanism of DNA cleavage and (7) bioorganic and bioinorganic chemistry of vanadium and phosphorous. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.