Introduction of GC and GC-MS into First and Second Year Chemistry Courses

将 GC 和 GC-MS 引入一年级和二年级化学课程

• 批准号: 9552104
• 负责人: Martin St. Clair
• 金额: $ 2.64万
• 依托单位: Coe College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-05-15 至 1997-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9552104&HistoricalAwards=false
• 关键词: Introduction; GC; MS; into; First

The purpose of this project is to incorporate gas chromatography and gas chromatography-mass spectrometry in the first 2 years of coursework. Students are introduced to chromatography and mass spectrometry through a series of three experiments in the first semester general chemistry course. The final experiment in this set involves sample collection, extraction, and analysis of herbicides from local lakes, streams, and rivers. Students in a new interdisciplinary Environmental Analysis course use gas chromatography to measure methane production from different types of soils and incorporate their results into a simple global climate change model. Organic Chemistry students make extensive use of gas chromatography for assessing purity of reaction products, and GC-MS to determine the identity of products and by-products. Analytical Chemistry students utilize deuterated internal standards and selected ion monitoring to measure the concentration of polyaromatic hydrocarbons in local lake sediments. Analytical students also utilize the GCs and GC-MS in mini-research projects of their own design. By acquainting students with the principles of chromatography and the unique problem solving capabilities of GC-MS early in their chemistry experience, the project (1) creates excitement in lower division courses; (2) gives students confidence in their ability to utilize sophisticated instrumentation; (3) allows upper level courses to focus on problem solving capabilities of the instrumentation, rather than on details of operation; and, (4) allows students to pursue student-initiated research.

该项目的目的是将气相色谱法和气相色谱-质谱法纳入前两年的课程中。 在第一学期普通化学课程中，学生将通过一系列三个实验向学生介绍色谱法和质谱法。 本组的最后一个实验涉及从当地湖泊、溪流和河流中采集、提取和分析除草剂样品。 新的跨学科环境分析课程的学生使用气相色谱法测量不同类型土壤的甲烷产量，并将其结果纳入简单的全球气候变化模型。 有机化学学生广泛使用气相色谱法来评估反应产物的纯度，并使用 GC-MS 来确定产物和副产物的身份。 分析化学学生利用氘代内标和选择离子监测来测量当地湖泊沉积物中多环芳烃的浓度。 分析学生还在自己设计的小型研究项目中使用 GC 和 GC-MS。 通过让学生在化学体验早期熟悉色谱原理和 GC-MS 独特的问题解决能力，该项目 (1) 在低年级课程中激发了兴趣； (2) 使学生对自己使用复杂仪器的能力充满信心； (3)让上层课程重点关注仪器解决问题的能力，而不是操作细节； (4) 允许学生进行学生发起的研究。