New Visions: Advanced Optical Imaging for the Undergraduate

Vicki J. Martin DUE 9552116 University of Notre Dame 1995 $ 50,000 Notre Dame， IN 46556 ILI -仪器项目：生命科学标题：新视野；为了加大对本科培训的改进力度，圣母大学生物科学系正在启动一项将先进生物成像纳入其核心课程的计划。这一决定是由于迫切需要采用创新的方法来记录、量化和分析生物过程。此外，应用光学、电子成像和基于计算的图像处理方面的新技术进步继续推动生物分子成像的前沿进入我们生活的方方面面，从医疗诊断到科学教育和研究。显然，如果我们打算保持这项技术的前沿，我们必须为本科生提供实验、探索和发现应用光学成像力量的机会。为了将生物成像整合到本科实验室中，我们正在开展各种实验，将重要的新型生物传感器和分子探针与最先进的电子探测器、高功率共聚焦光学以及用于动态细胞、发育和生理过程研究的复杂软件程序相结合。这些练习训练学生掌握电子图像采集、处理和分析的基本知识，同时强调基于计算机的数字光学仪器的功能及其作为生物研究定量工具的用途。

Vicki J. Martin DUE 9552116 University of Notre Dame FY1995 $ 50,000 Notre Dame, IN 46556 ILI - Instrumentation Project: Life Sciences Title: New Visions: Advanced Optical Imaging for the Undergraduate In an increasing effort to expand improvements in undergraduate training, the Department of Biological Science at Notre Dame is initiating a program to integrate advanced bioimaging into its core curriculum. This decision is stimulated by a pressing need to incorporate innovative methods for recording, quantifying, and analyzing biological processes. In addition, new technological advancements in applied optics, electronic imaging, and computational-based image processing continue to drive the frontier of biomolecular imaging into all elements of our lives from medical diagnostics to science education and research. Clearly, if we plan to stay at the frontier of this technology, we must provide undergraduates with the opportunity to experiment, explore, and discover the power of applied optical imaging. To integrate bioimaging into undergraduate laboratories, we are carrying out a variety of experiments that combine the use of important new biosensors and molecular probes with state-of-the-art electronic detectors, high-powered confocal optics, and sophisticated software programs for the study of dynamic cell, developmental, and physiological processes. These exercises are training students in the nuts and bolts of electronic image acquisition, processing, and analysis, while emphasizing the power of computer-based digital optical instrumentation and its use as a quantitative tool for biological investigation.