MRI: New Visions: Acquisition of a Confocal Laser Scanning Microscope for Integrating Research and Research Training in Biology

MRI：新愿景：购买共焦激光扫描显微镜，用于整合生物学研究和研究培训

• 批准号: 0421115
• 负责人: Vicki Martin
• 金额: $ 35.2万
• 依托单位: Appalachian State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0421115&HistoricalAwards=false
• 关键词: MRI; New; Visions; Acquisition; Confocal

This award provides support for acquisition of a modern Confocal Laser Scanning Microscope (CLSM) to be housed in a microscopy facility accessible to all faculty of the institution and their students, and to faculty and students at other academic institutions in the region. A full-time Director of the Microscopy Facility will train users of the CLSM. The microscope is expected to both improve and expand research and research training at the Institution through its use in research experimentation, research training of faculty and students, integration of experimental design/research training into formal classroom and laboratory instruction, and community outreach efforts. Among the research programs to benefit from availability of the instrument are studies of eye designs in basal metazoans, analysis of arthropod head segmentation, efforts to elucidate the effect of sphingolipid changes and of senescence on membrane microdomain structure and function, and studies of embryonic control mechanisms in model crustaceans. The planned studies will contribute new knowledge to the fields of cell biology, developmental biology, neurobiology, physiology, and evolutionary biology. All projects will provide research training opportunities for undergraduate and graduate students, and, together with faculty users, students will participate in a monthly student/ faculty research seminar series where experimental design, bioimaging, and current literature will be discussed. Student users will be encouraged to present their findings at professional meetings and to publish their results in peer reviewed journals. Additional faculty and students in 8 departments are expected to use confocal imaging in their research and research training activities. Use or demonstration of the CLSM will be incorporated into biology teaching laboratories and science education classes at the institution and at some neighboring community colleges. The microscopy facility is expected to serve as a regional facility, thus permitting access to a state of the art CLSM for faculty and students at nearby institutions that currently lack this important tool for modern cell and developmental biology.

该奖项为购买一台现代共聚焦激光扫描显微镜（CLSM）提供了支持，该显微镜设备将被安置在一个显微镜设施中，供该机构的所有教师及其学生以及该地区其他学术机构的教师和学生使用。显微镜设备的全职主任将培训CLSM的用户。该显微镜有望通过在研究实验、教师和学生的研究培训、将实验设计/研究培训整合到正式的课堂和实验室教学以及社区外展工作中来改善和扩大研究所的研究和研究培训。利用该仪器的研究项目包括：基础后生动物眼睛设计的研究、节肢动物头部分割的分析、鞘脂变化和衰老对膜微结构域结构和功能的影响的研究，以及模式甲壳类动物胚胎控制机制的研究。计划中的研究将为细胞生物学、发育生物学、神经生物学、生理学和进化生物学等领域贡献新的知识。所有项目将为本科生和研究生提供研究培训机会，并且，与教师用户一起，学生将参加每月一次的学生/教师研究系列研讨会，其中将讨论实验设计，生物成像和当前文献。学生用户将被鼓励在专业会议上展示他们的发现，并在同行评审的期刊上发表他们的结果。8个系的其他教师和学生预计将在他们的研究和研究培训活动中使用共聚焦成像。CLSM的使用或演示将被纳入该机构和一些邻近社区学院的生物教学实验室和科学教育课程。显微镜设备预计将作为一个区域设施，从而允许附近机构的教师和学生使用最先进的CLSM，这些机构目前缺乏现代细胞和发育生物学的重要工具。