Signaling to plant immunity responses (PathoNet)

主要目标：通过先进的基因组学工具提高对病原体感知和激活的信号通路的理解，并解决这些通路调节的功能如何使植物适应病原环境。为实现这一目标，建立一个新的研究平台，包括采用和进一步发展基因组学来回答生物学问题，重点是PAMP诱导的信号，特别是，我们将解开蛋白激酶和磷酸酶信号复合物，磷酸化蛋白质靶点，并将这些事件与植物代谢反应和病原体诱导的免疫功能联系起来。在这个项目中，我们聚集了领先的研究团队，研究PAMP诱导的信号转导的不同方面，涉及受体样激酶（RLK），有丝分裂原活化蛋白激酶（MAPK）和相对的蛋白磷酸酶，PP2C。我们使用和开发先进的技术来跟踪蛋白质磷酸化的动态变化，磷酸化蛋白质组和代谢组的系统分析响应特定的PAMP信号。建立这个新的强有力的互动国际团队将有助于达到植物科学对生物胁迫信号的“临界质量”。

Main objective: To improve understanding of pathogen perception and activated signaling pathways via advanced genomics tools and to.resolve how functions regulated by these pathways enable plant adaptation to pathogenic environment. Towards this aim, establish a novel research platform that includes employing and further developing genomics to answer biological questions focusing on PAMP-induced signaling In particular, we will unravel protein kinase and phosphatase signaling complexes, phosphorylated protein targets, and to link these events to plant metabolic responses and pathogen induced immunity functions. Within this project we have gathered leading research teams that study different aspects of PAMP induced signal transduction with the involvement of receptor-like kinases (RLKs), mitogen-activated protein kinases (MAPKs) and on the opposing protein phosphatases, PP2Cs. We use and develop advanced technologies to follow the dynamic changes in phosphorylation of proteins, the phosphoproteome and systemic analysis of the metabolome in response to specific PAMP signals. Building this new strongly interacting international team will help to reach the "critical mass" of plant science on biotic stress signaling.