CAREER: Tandem Repeats: Sequence Comparison and Search Algorithms

职业：串联重复：序列比较和搜索算法

• 批准号: 9623532
• 负责人: Gary Benson
• 金额: $ 20.5万
• 依托单位: Icahn School of Medicine at Mount Sinai
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-15 至 2000-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9623532&HistoricalAwards=false
• 关键词: CAREER; Tandem; Repeats; Sequence; Comparison

This project focuses on expanding the capabilities of the present (DNA) sequence analysis algorithms with respect to comparing sequences and detecting features. In particular, the project concentrates on:(1) developing methods for quantifying the relatedness of biological sequences under a broader model of mutational events, than the currently used substitution-indel model, and (2) improving methods for detecting tandem repeats in sequences. The Integrated Educational Plan of this CAREER Grant includes(a)developing a curriculum for graduate study in computational and mathematical biology, (b) developing courses and course materials, including lecture notes, exercises, programming projects and extensive bibliographies, that cover combinatorial and algorithmic topics in sequence alignment, DNA sequencing, DNA physical mapping, DNA physical mapping, and prediction of protein folding and RNA folding, and phylogenetic tree construction, (c) instituting a summer training course for new researchers in computational biology.***

该项目的重点是扩展目前（DNA）序列分析算法在比较序列和检测特征方面的能力。 特别是，该项目集中于：（1）开发在更广泛的突变事件模型下量化生物序列相关性的方法，而不是目前使用的取代-indel模型，以及（2）改进检测序列中串联重复的方法。该职业资助的综合教育计划包括：（a）开发计算和数学生物学研究生课程，（B）开发课程和课程材料，包括课堂讲稿、练习、编程项目和广泛的参考书目，涵盖序列比对、DNA测序、DNA物理图谱、DNA物理图谱、蛋白质折叠和RNA折叠的预测，以及系统发育树的构建，（c）为计算生物学的新研究人员开设夏季培训课程。