TRDB: A Multi-genome Database of Tandem Repeats

串联重复是核苷酸序列的两个或更多个相邻的、通常近似的拷贝的出现。 串联重复序列具有已知的功能作用，包括编码功能丧失、开关和作为基因表达的修饰剂。串联重复序列是染色体结构的主要组成部分。 它们可用于遗传连锁分析、细菌菌株分型、DNA指纹分析和短时间内DNA变化的研究。新的处理整个基因组的软件使识别串联重复序列变得更加容易。 快速分析允许重复序列的鉴定和注释，聚类成家族以供进一步研究。 多基因组串联重复数据库将汇集有关重复的信息，并作为开发新工具的平台。 这些算法包括比较和聚类重复，以及用于确定拷贝数多态性的预测标准。 这将进一步使得能够注释重复序列和重复序列家族，包括基因组环境、拷贝数多态性、全基因组性质和家族性质。所有这些都将通过一个网站提供，该网站具有综合的数据可视化和数据模型规格，可转换为其他格式。

A tandem repeat is an occurrence of two or more adjacent, often approximate copies of a sequence of nucleotides. Tandem repeats have known functional roles, including coding with loss of function, switching, and acting as modifiers of gene expression. Tandem repeats are primary components of chromosomal structures. They are useful for genetic linkage analysis, bacterial strain typing, DNA fingerprinting and studies of changes in DNA over short time scales.Identification of tandem repeats has been made easier by new software that processes the entire genome. The rapid analysis permits identification and annotation of repeats, clustering into families for further study. A multi-genome Tandem Repeats Database will bring together information about repeats as well as serving as the platform for development of new tools. These include algorithms to compare and cluster repeats, as well as for identifying predictive criteria for copy number polymorphisms. This will further enable annotation of repeats and of repeat families, including genomic environment, copy number polymorphisms, whole genome properties and family properties. All of this will be available through a web site with integrated data visualization and data model specification for transfer to other formats.