TRDB: A Multi-genome Database of Tandem Repeats

串联重复是两个或多个相邻的，通常是核苷酸序列的近似拷贝。串联重复序列具有已知的功能作用，包括编码功能丧失、转换和作为基因表达的修饰因子。串联重复序列是染色体结构的主要组成部分。它们可用于遗传连锁分析、细菌菌株分型、DNA指纹和短时间内DNA变化的研究。通过处理整个基因组的新软件，串联重复序列的鉴定变得更加容易。快速分析允许重复的识别和注释，聚类成家族进一步研究。多基因组串联重复序列数据库将汇集有关重复序列的信息，并作为开发新工具的平台。这些包括比较和聚类重复的算法，以及用于识别拷贝数多态性的预测标准的算法。这将进一步实现重复序列和重复序列家族的注释，包括基因组环境、拷贝数多态性、全基因组特性和家族特性。所有这些都将通过一个网站提供，该网站集成了数据可视化和数据模型规范，以便转换为其他格式。

A tandem repeat is an occurrence of two or more adjacent, often approximate copies of a sequence of nucleotides. Tandem repeats have known functional roles, including coding with loss of function, switching, and acting as modifiers of gene expression. Tandem repeats are primary components of chromosomal structures. They are useful for genetic linkage analysis, bacterial strain typing, DNA fingerprinting and studies of changes in DNA over short time scales.Identification of tandem repeats has been made easier by new software that processes the entire genome. The rapid analysis permits identification and annotation of repeats, clustering into families for further study. A multi-genome Tandem Repeats Database will bring together information about repeats as well as serving as the platform for development of new tools. These include algorithms to compare and cluster repeats, as well as for identifying predictive criteria for copy number polymorphisms. This will further enable annotation of repeats and of repeat families, including genomic environment, copy number polymorphisms, whole genome properties and family properties. All of this will be available through a web site with integrated data visualization and data model specification for transfer to other formats.