VPW: Mathematical Analysis of the Early Events in Cell Signaling

VPW：细胞信号传导早期事件的数学分析

• 批准号: 9627118
• 负责人: Carla Wofsy
• 金额: $ 12.99万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 1998-08-18
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9627118&HistoricalAwards=false
• 关键词: VPW; Mathematical; Analysis; Early; Events

This research uses methods of mathematics and statistics, in conjunction with experimental work in two cell biology laboratories, to clarify the first responses of cells to extracellular "signaling" molecules. Hormones, cytokines, immune complexes and antigens all initiate cellular responses through interactions with specific cell surface "receptors." Diverse systems have in common the two initial events in cell signaling that this project addresses, the aggregation of cell surface receptors, followed by the phosphorylation of tyrosine on receptors and non-receptor proteins. The first collaboration investigates mechanisms and effects of receptor aggregation through the analysis of molecular point patterns on electron microscope images. The second collaboration focusses on mechanisms by which aggregated receptors mediate tyrosine phosphorylation. A proposed model appears to be consistent with previously obtained data and makes additional testable predictions. Interactive activities include: teaching a graduate course on "Stochastic Models in Biology and Chemistry," and organizing special visits of women with active research programs in Mathematical Biology, Biostatistics, Biophysics, and related sciences. Activities aimed at fostering interactions of students with the visitors include preparatory seminars preceding the visits, a student-oriented talk as part of each visit, and organized discussions between students and visitors.

这项研究使用数学和统计学的方法，结合两个细胞生物学实验室的实验工作，阐明细胞对细胞外“信号”分子的第一反应。 激素、细胞因子、免疫复合物和抗原都通过与特定细胞表面“受体”相互作用来启动细胞反应。“不同的系统在细胞信号传导中有两个共同的初始事件，即细胞表面受体的聚集，然后是受体和非受体蛋白上酪氨酸的磷酸化。 第一个合作研究机制和受体聚集的影响，通过分析电子显微镜图像上的分子点模式。 第二个合作重点是聚集受体介导酪氨酸磷酸化的机制。 提出的模型似乎与以前获得的数据一致，并作出额外的可测试的预测。 互动活动包括：教授研究生课程“生物学和化学中的随机模型”，并组织在数学生物学、生物统计学、生物物理学和相关科学领域从事积极研究项目的妇女进行特别访问。 旨在促进学生与来访者互动的活动包括：访问前的预备研讨会、每次访问时面向学生的讲座以及学生与来访者之间有组织的讨论。