Mathematical Sciences: Mathematical Analysis of Receptor Aggregation on Cell Surfaces and its Effects on Cell Function

数学科学：细胞表面受体聚集及其对细胞功能影响的数学分析

• 批准号: 9101969
• 负责人: Carla Wofsy
• 金额: $ 18万
• 依托单位: University of New Mexico
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-15 至 1994-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9101969&HistoricalAwards=false
• 关键词: Mathematical; Sciences; Analysis; Receptor; Aggregation

The principal investigator will work in collaboration with both experimental and theoretical biologists in the area of cell surface receptors. Biological cells sense their environment primarily through the interaction of cell surface receptors with specific extracellular ligands. These molecular interactions serve as signals, initiating cell responses to hormones, neurotransmitters, immune response mediators and other molecules. The planned work is the mathematical component of theoretical/experimental collaborations aimed at identifying particular cell signals and response pathways. These models are essential for the understanding of the biology, because the mechanisms cannot be observed directly. The mathematical tools will involve the analysis of spatial data. The principal investigator will work in collaboration with both experimental and theoretical biologists in the area of cell surface receptors. The planned work is the mathematical component of this collaboration which is aimed at identifying particular cell signals and response pathways. These models are essential for the understanding of the biology, because the mechanisms cannot be observed directly. The mathematical tools will involve the analysis of spatial data.

首席研究员将与细胞表面受体领域的实验和理论生物学家合作。 生物细胞主要通过细胞表面受体与特定细胞外配体的相互作用来感知其环境。 这些分子相互作用充当信号，启动细胞对激素、神经递质、免疫反应介质和其他分子的反应。 计划的工作是理论/实验合作的数学组成部分，旨在识别特定的细胞信号和反应途径。 这些模型对于理解生物学至关重要，因为其机制无法直接观察。 数学工具将涉及空间数据的分析。 首席研究员将与细胞表面受体领域的实验和理论生物学家合作。 计划的工作是此次合作的数学组成部分，旨在识别特定的细胞信号和反应途径。 这些模型对于理解生物学至关重要，因为其机制无法直接观察。 数学工具将涉及空间数据的分析。