CAREER: In-situ Determination of Pesticides and Other Environmental Pollutants with a Fiber Optic, Surface Resonance Based Sensor

职业：使用基于光纤、表面共振的传感器对农药和其他环境污染物进行原位测定

• 批准号: 9702476
• 负责人: Karl Booksh
• 金额: $ 28.5万
• 依托单位: Arizona State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9702476&HistoricalAwards=false
• 关键词: CAREER; situ; Determination; Pesticides; Other

This Faculty Early Career Development (CAREER) project, supported in the Analytical and Surface Chemistry Program, focusses on the development and characterization of novel fiber-optic sensors for the determination of part-per-billion concentrations of pesticides in real environmental samples. Professor Booksh and his students at Arizona State University will develop a variety of such sensors including antibody immobilized devices that utilize attenuated total reflectance of their surface plasmon resonance signals in order to achieve selectivity and sensitivity. The probe geometry will be optimized for this application and multivariate calibration algorithms will be used to improve data quality when system parameters vary. This CAREER research project will also expose students at the undergraduate and graduate levels to the power of multivariate methods when analytical measurements involve complex real world samples. Professor Booksh will also mentor disabled students interested in scientific careers. The determination of the concentrations of pesticides in the environment is an important health problem that is highly complex due to the variability of real world sample composition. Professor Booksh and his students at Arizona State University will develop fiber-optic sensors based on antibody/antigen reactions that produce analytical signals that can be reliably interpreted over time. This CAREER project will provide students with a stimulating research experience in an area of immense societal importance. The extreme sensitivity and selectivity of antibody/antigen reactions coupled with fiber-optic sensor probes will be exploited using attenuated total reflectance of surface plasmon resonance signals that follow these reactions. In addition to the pedagogical value of teaching students useful applications of this chemistry Professor Booksh will mentor disabled students interested in scientific careers.

该学院的早期职业发展（CAREER）项目得到了分析和表面化学项目的支持，重点是新型光纤传感器的开发和表征，用于测定真实环境样品中十亿分之一的农药浓度。 亚利桑那州立大学的 Booksh 教授和他的学生将开发各种此类传感器，包括抗体固定装置，这些装置利用表面等离子共振信号的衰减全反射率来实现选择性和灵敏度。 探头几何形状将针对该应用进行优化，并且当系统参数变化时，将使用多变量校准算法来提高数据质量。 当分析测量涉及复杂的现实世界样本时，该职业研究项目还将让本科生和研究生级别的学生接触到多元方法的力量。 布克什教授还将指导对科学职业感兴趣的残疾学生。 环境中农药浓度的测定是一个重要的健康问题，由于现实世界样品成分的可变性，该问题非常复杂。 亚利桑那州立大学的 Booksh 教授和他的学生将开发基于抗体/抗原反应的光纤传感器，这些传感器会产生可以随着时间的推移进行可靠解释的分析信号。 这个职业项目将为学生提供一个具有巨大社会重要性的领域的激动人心的研究经验。 与光纤传感器探针相结合的抗体/抗原反应的极高灵敏度和选择性将利用这些反应后表面等离振子共振信号的衰减全反射率。 除了教授学生这种化学的有用应用的教学价值外，布克什教授还将指导对科学职业感兴趣的残疾学生。