CAREER: In-situ Determination of Pesticides and Other Environmental Pollutants with a Fiber Optic, Surface Resonance Based Sensor

该学院早期职业发展（CAREER）项目，在分析和表面化学计划的支持下，专注于开发和表征新型光纤传感器，用于测定真实的环境样品中农药的十亿分之一浓度。 亚利桑那州立大学的Booksh教授和他的学生将开发各种这样的传感器，包括利用其表面等离子体共振信号的衰减全反射的抗体固定装置，以实现选择性和灵敏度。 探头几何形状将针对该应用进行优化，当系统参数变化时，将使用多变量校准算法来提高数据质量。 这个职业生涯的研究项目也将暴露在本科生和研究生水平的多元方法的力量时，分析测量涉及复杂的真实的世界样本。 布克什教授还将指导对科学事业感兴趣的残疾学生。 由于真实的世界样品组成的可变性，确定环境中农药的浓度是一个非常复杂的重要健康问题。 亚利桑那州立大学的Booksh教授和他的学生将开发基于抗体/抗原反应的光纤传感器，这些传感器产生的分析信号可以随着时间的推移而可靠地解释。 这个职业生涯项目将为学生提供一个具有巨大社会重要性的领域的刺激性研究经验。 与光纤传感器探针耦合的抗体/抗原反应的极端灵敏度和选择性将利用这些反应之后的表面等离子体共振信号的衰减全反射。 除了教学生有用的应用这种化学教授布克什的教学价值将指导残疾学生感兴趣的科学事业。

This Faculty Early Career Development (CAREER) project, supported in the Analytical and Surface Chemistry Program, focusses on the development and characterization of novel fiber-optic sensors for the determination of part-per-billion concentrations of pesticides in real environmental samples. Professor Booksh and his students at Arizona State University will develop a variety of such sensors including antibody immobilized devices that utilize attenuated total reflectance of their surface plasmon resonance signals in order to achieve selectivity and sensitivity. The probe geometry will be optimized for this application and multivariate calibration algorithms will be used to improve data quality when system parameters vary. This CAREER research project will also expose students at the undergraduate and graduate levels to the power of multivariate methods when analytical measurements involve complex real world samples. Professor Booksh will also mentor disabled students interested in scientific careers. The determination of the concentrations of pesticides in the environment is an important health problem that is highly complex due to the variability of real world sample composition. Professor Booksh and his students at Arizona State University will develop fiber-optic sensors based on antibody/antigen reactions that produce analytical signals that can be reliably interpreted over time. This CAREER project will provide students with a stimulating research experience in an area of immense societal importance. The extreme sensitivity and selectivity of antibody/antigen reactions coupled with fiber-optic sensor probes will be exploited using attenuated total reflectance of surface plasmon resonance signals that follow these reactions. In addition to the pedagogical value of teaching students useful applications of this chemistry Professor Booksh will mentor disabled students interested in scientific careers.