SGER: Single Nanoparticle Surface Plasmon Resonance Imaging

SGER：单纳米粒子表面等离子共振成像

• 批准号: 0918189
• 负责人: Karl Booksh
• 金额: $ 15万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0918189&HistoricalAwards=false
• 关键词: SGER; Single; Nanoparticle; Surface; Plasmon

"This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5)."Professor Karl S. Booksh of the University of Delaware is supported by the Analytical and Surface Chemistry Program in the Division of Chemistry to develop a scanning, single particle surface plasmon resonance spectroscopy technique to be applied for label-free imaging of nanoscale heterogeneous materials. A single gold or silver nanoparticle will be placed on the tip of an optical fiber probe of a near-field scanning optical microscope. The plasmon field will be shaped and focused by adjusting the size and morphology of the nanoparticle probe. Refractive index changes on the probed surface will affect the surface plasmon resonance frequency of the particle immobilized at the tip of the probe. This will enable the high-resolution mapping of local dielectric constants of nanoscale heterogeneous materials without the need for dyes or reporter molecules. Such a high resolution, non-invasive imaging method is currently not available. The proposed imaging technique will be useful for characterization of surfaces of materials such as SAMs, lipid bilayers, and soft polymers, and will lead to innovations in nanoscience and technology, surface chemistry, and biotechnology.

“该奖项是根据 2009 年美国复苏和再投资法案（公法 111-5）提供资金的。” 特拉华大学 Karl S. Booksh 教授在化学系分析和表面化学项目的支持下，开发了一种扫描、单粒子表面等离子体共振光谱技术，用于纳米级异质材料的无标记成像。 将单个金或银纳米颗粒放置在近场扫描光学显微镜的光纤探针的尖端上。通过调整纳米颗粒探针的尺寸和形态，可以形成和聚焦等离子体场。 被探测表面的折射率变化将影响固定在探针尖端的颗粒的表面等离子体共振频率。这将能够在不需要染料或报告分子的情况下对纳米级异质材料的局部介电常数进行高分辨率绘图。 目前还没有这种高分辨率、非侵入性成像方法。 所提出的成像技术将有助于表征 SAM、脂质双层和软聚合物等材料的表面，并将带来纳米科学和技术、表面化学和生物技术的创新。