Purchase of a Tandem Mass Spectrometer for Research in Chemistry

购买串联质谱仪用于化学研究

• 批准号: 9708413
• 负责人: C. Poulter
• 金额: $ 29.25万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 1998-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9708413&HistoricalAwards=false
• 关键词: Purchase; Tandem; Mass; Spectrometer; Research

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program and the Office of Multidisciplinary Activities (OMA) will assist the Department of Chemistry at University of Utah to acquire a tandem mass spectrometer. This equipment will enhance research in a number of areas including the following: (1) RNA-binding polyamides via encoded combinatorial synthesis, (2) phosphorus-containing molecules based on 2'-deoxynucleosides, (3) analysis of RNA-binding proteins and peptides, (4) DNA mismatch recognition and repair by metalloenzyme MutY, and oxidative alkylation and degradation of guanine in DNA and RNA structures. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The addition of the technique of electrospray extends the range of MS to proteins and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest techniques available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry.

这份来自化学研究仪器和设施（CRIF）项目和多学科活动办公室（OMA）的合同将帮助犹他大学化学系获得串联质谱仪。该设备将加强以下领域的研究：(1)通过编码组合合成的RNA结合聚酰胺，(2)基于2'-脱氧核苷的含磷分子，(3)RNA结合蛋白和肽的分析，(4)金属酶MutY的DNA错配识别和修复，以及DNA和RNA结构中鸟嘌呤的氧化烷基化和降解。质谱（MS）是一种用于探测内部结构细节和获得大量有机、生物有机和有机金属分子的分子组成的技术。电喷雾技术的加入将质谱的范围扩展到蛋白质和核酸分子量，远远超过任何其他技术。电喷雾电离结合高分辨率提供了质谱分析的最新技术。它为化学家提供了表征化合物的最有力的工具之一。在质谱法中获得这种能力对于化学许多领域的前沿研究的进行是必不可少的。