Purchase of a Tandem Mass Spectrometer for Research in Chemistry

该奖项由化学研究仪器和设施 CRIF计划和多学科活动办公室（OMA）将 协助犹他州大学化学系获得 串联质谱仪该设备将加强研究， （1）RNA结合聚酰胺， 编码组合合成，（2）含磷分子 基于2 '-脱氧核苷，（3）RNA结合蛋白的分析， 肽，（4）金属酶MutY对DNA错配的识别和修复， DNA和RNA中鸟嘌呤的氧化烷基化和降解 结构. 质谱（MS）是用于探测紧密结构的技术， 详细信息，并获得大量的分子组成， 有机、生物有机和有机金属分子。的加入 电喷雾技术将质谱的范围扩展到蛋白质和核酸 酸的分子量远远超过任何其他技术。使用 电喷雾电离结合高分辨率提供了 质谱分析的最新技术。它为化学家提供了 一个最强大的工具，可用于表征 化合物.在质谱分析中获得这种能力是 对许多领域的前沿研究至关重要， 化学.

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program and the Office of Multidisciplinary Activities (OMA) will assist the Department of Chemistry at University of Utah to acquire a tandem mass spectrometer. This equipment will enhance research in a number of areas including the following: (1) RNA-binding polyamides via encoded combinatorial synthesis, (2) phosphorus-containing molecules based on 2'-deoxynucleosides, (3) analysis of RNA-binding proteins and peptides, (4) DNA mismatch recognition and repair by metalloenzyme MutY, and oxidative alkylation and degradation of guanine in DNA and RNA structures. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The addition of the technique of electrospray extends the range of MS to proteins and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest techniques available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry.