Integration of NMR Spectroscopy into the Undergraduate Chemistry Curriculum

核磁共振光谱学作为一种用于化学和相关领域的工具，如生物化学、分子生物学、药剂学和药物化学，已经取得了卓越的地位。与磁共振成像(MRI)密切相关的学科将这项技术的应用范围扩展到临床医学和材料科学等领域。因此，让进入这些领域的本科生清楚地了解核磁共振的基本原理是很重要的。继续在中学或大专阶段教授物理科学的学生应该在这项技术方面有坚实的基础，这一点加倍重要。然而，满足数百名大二有机化学学生的需求是一项艰巨的任务，尽管如此，我们的化学系正在支持一项倡议，让所有学习化学的学生接触到他们未来职业生涯中可能遇到的尖端设备。一台由现有的9.4特斯拉磁铁、一个新的400 MHz控制台、样品搬运机器人、脉冲场梯度系统、脉冲场梯度探头和垫片系统组成的核磁共振波谱仪将作为这一倡议的基础。该光谱仪的主机工作站通过以太网与局域网相连。考虑到这种自动化水平，每周数百个样品的吞吐量是完全现实的。不急于采取的步骤是学生与数据的交互。每个学生都要花费尽可能多的时间来处理、检查数据并将其合并到实验室报告中。适当的核磁共振实验正在文献中的基础上进行修改，并被整合到大二的有机化学课程中，进一步扩展了佛罗里达州立大学的模型，在大班中使用核磁共振。此外，核磁共振被用于定性有机化学、高级分析化学、高级物理化学和生物化学课程，以及参与本科生研究的学生。

Chemistry (12)Nuclear magnetic resonance (NMR) spectroscopy has attained a preeminent position as a tool for use in chemistry and related fields, such as biochemistry, molecular biology, pharmaceutics, and medicinal chemistry. The closely related discipline of Magnetic Resonance Imaging (MRI) extends the reach of this technology into such fields as clinical medicine and material science. Thus, it is important that undergraduate students entering any of these fields be given a clear understanding of the principles basic to NMR. It is doubly important that students who go on to teach physical science at the secondary or post-secondary level should have a firm grounding in this technology. However, meeting this need for a class of several hundred sophomore organic chemistry students is a daunting task, Nevertheless, our Chemistry Department is supporting an initiative to expose all students taking chemistry to sophisticated equipment of the types they are likely to encounter in their future careers. An NMR spectrometer consisting of an existing 9.4 Tesla magnet, a new 400 MHz console, sample handling robot, pulsed-field-gradient system, pulsed-field-gradient probe, and shim system is serving as the basis for this initiative. The host workstation of this spectrometer is connected to the LAN via ethernet. Given this level of automation, a throughput of hundreds of samples per week is entirely realistic. The step that is not being rushed is the interaction of the student with the data. Each student spends as much time as desired processing, examining, and incorporating the data into laboratory reports. Appropriate NMR experiments are being modified from those available in the literature and are being integrated into the large sophomore organic chemistry course, further extending the model at Florida State University for using an NMR in large classes. In addition, the NMR is being used in the qualitative organic chemistry, advanced analytical chemistry, advanced physical chemistry, and biochemistry courses, and by students involved in undergraduate research.