Molecular Structure and Function of the Arabidopsis RPM1 Disease Resistance Gene

详细了解导致植物抗病的分子事件是一个有趣的基础研究挑战。病害反应的遗传控制通常是由病原基因位点的等位基因与相应植物抗病位点的等位基因之间的特定相互作用决定的。该领域最近的突破包括第一批抗性基因的分子鉴定，包括RPM1，这是拟议工作的重点。由Rpm1编码的蛋白以一种尚不清楚的方式识别病原体来源的因子。RPM1蛋白的参与触发信号转导和防御反应。一个重要的结果是，RPM1编码一种双重特异性，通过引发对另一种不相关病原体功能的抗性。建议的工作将解决RPM1蛋白的结构-功能关系，其亚细胞定位以及与RPM1相互作用的蛋白质的数量和性质。

9724075 Dangl A detailed understanding of the molecular events leading to plant disease resistance presents an interesting basic research challenge. Genetic control of disease reactions is often determined by specific interactions between alleles of a pathogen gene locus and an allele of the corresponding plant disease resistance locus. Recent breakthroughs in this field include the molecular identification of the first resistance genes, including RPM1 which is the focus of the proposed work. The protein(s) encoded by Rpm1 recognize pathogen-derived factors in an as yet unknown manner. Engagement of the RPM1 protein triggers signal transduction and defense responses. One important result is that RPM1 encodes a dual specificity , by eliciting resistance to the action of another, unrelated pathogen function. The proposed work will address structure-function relationships of the RPM1 protein, its subcellular localization and the number and nature of proteins with which RPM1 interacts.