Arabidopsis 2010: The Arabidopsis RPM1 Disease Resistance Signaling Network

拟南芥 2010：拟南芥 RPM1 抗病信号网络

• 批准号: 0114795
• 负责人: Jeffery Dangl
• 金额: $ 121.43万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0114795&HistoricalAwards=false
• 关键词: Arabidopsis; 2010; RPM1; Disease; Resistance

Determining the function of a network of genesDefinition of "determining the function"In our project, we will define the function of approximately 10 new genes from Arabidopsis that are functionally related because they are part of the RPM1 disease resistance pathway. Our definition of function will entail:1. Detailed information on the role of these genes in disease resistance.2. Broader definition of extra functions that we may uncover for these genes. For example, we already know that reduction of function of at least two of them causes meristem defects. At present, this may be simple pleiotropy. It also may be relevant, meaning that the genes in question have additional functions in plant growth. URLs where the public can get information on their accession numbers in GenBank or other identifiers in a publicly accessible databaseOur data will be published and our results will also be available on our lab web site at:http://www.bio.unc.edu/faculty/dangl/lab/superpage.htmlAs an example of how we release web based data, see:http://www.bio.unc.edu/faculty/dangl/lab/sar/What, how and where the results will be sharedWe will share our results well before publication at the annual Arabidopsis meeting.Significance of the proposed work in relation to the 2010 Project objectivesOur work will dovetail with more general functional genomics proposals funded in 2010. It is necessary to incorporate hypothesis driven functional genomics results, such as the data we intend to generate, with the gene family and whole genome data generated by others.Broader ImpactDisease resistance is a significant problem in agriculture. We will add to the body of knowledge that will eventually lead to more effective control of plant disease. This is vital because we currently lose up to 30% of crop yield to pathogens and pests.

确定基因网络的功能“确定功能“的定义在我们的项目中，我们将定义来自拟南芥的大约10个新基因的功能，这些基因在功能上是相关的，因为它们是RPM 1抗病途径的一部分。我们对函数的定义需要：1。这些基因在抗病中的作用的详细信息。更广泛的定义，我们可能会发现这些基因的额外功能。例如，我们已经知道，其中至少两个功能的减少会导致分生组织缺陷。目前，这可能是简单的多效性。它也可能是相关的，这意味着所讨论的基因在植物生长中具有额外的功能。URL，公众可以在其中获得关于其在GenBank中的登录号或在可公开访问的数据库中的其他标识符的信息我们的数据将被发布，我们的结果也将在我们的实验室网站上提供：http://www.bio.unc.edu/faculty/dangl/lab/superpage.htmlAs我们如何发布基于网络的数据的示例，请参见：http：//www.bio.unc.edu/faculty/dangl/lab/sar/What,我们将在拟南芥年会上发表之前分享我们的研究结果。建议的工作与2010年项目目标相关的意义我们的工作将与2010年资助了更多的一般功能基因组学提案。有必要将假设驱动的功能基因组学结果（如我们打算生成的数据）与其他人生成的基因家族和全基因组数据相结合。更广泛的影响抗病性是农业中的一个重要问题。我们将增加知识，最终将导致更有效地控制植物疾病。这一点至关重要，因为我们目前因病原体和害虫损失了高达30%的作物产量。