A General Neural Simulation System for Computational Neurobiology

计算神经生物学的通用神经模拟系统

基本信息

  • 批准号:
    9724137
  • 负责人:
  • 金额:
    $ 79.91万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    1997
  • 资助国家:
    美国
  • 起止时间:
    1997-10-01 至 2000-09-30
  • 项目状态:
    已结题

项目摘要

This project is the comprehension redesign of the neural simulation toll referred to as GENESIS (GEneral NEural SImulation System). GENESIS was developed initially as part of the P.I.'s ongoing efforts to build realistic models of nervous systems. GENESIS has been made available for use to laboratories outside Caltech for research and education, and has become an important tool for the computational neuroscience community. The overall design objective for the GENESIS project is to provide neurobiologists with a powerful tool for simulating neruobiological systems, while at the same time promoting the interactions between different modeling efforts. We will concentrate on two areas: first we will continue to provide ongoing user support. This includes on-line services, continued development of documentation, bug fixes, and promotion of collaborations between GENESIS users and between GENESIS developers. The second major focus of our activities will be the redesign of GENESIS itself. The basic software design of the project has not changed substantially since its inception in 1986. It is now time to completely redesign GENESIS to provide far more efficient portability across platforms free extensibility and exchange of code, flexibility lump missing parameters and compartments, and provide granularity along multiple axes. Achieving these goals should result in a move useful, more easily federated system which is far less expensive to extend and maintain. The redesign is beginning by first taking a parallel systems view point, rather than starting with a sequential platform and later parting to parallel. This work is supported by the Computational Neuroscience program, and the neuroscience's cluster (all in Bio). This effort will focus on both support for parallel architectures as well as new graphics languages.
该项目是对神经模拟工具GENESIS(通用神经模拟系统)的全面重新设计。 GENESIS最初是作为P.I.正在努力建立逼真的神经系统模型。 GENESIS已被加州理工学院以外的实验室用于研究和教育,并已成为计算神经科学界的重要工具。 GENESIS项目的总体设计目标是为神经生物学家提供模拟神经生物学系统的强大工具,同时促进不同建模工作之间的相互作用。 我们将专注于两个方面:首先,我们将继续提供持续的用户支持。 这包括联机服务、继续编写文件、修正错误以及促进GENESIS用户之间和GENESIS开发人员之间的合作。 我们活动的第二个主要重点将是重新设计GENESIS本身。 该项目的基本软件设计自1986年开始以来没有实质性变化。 现在是完全重新设计GENESIS的时候了,以提供跨平台的更有效的可移植性、自由的可扩展性和代码交换、灵活性、缺少的参数和分隔,并提供沿沿着多个轴的粒度。 实现这些目标应该会产生一个有用的、更容易的联邦系统,而且扩展和维护成本要低得多。 重新设计首先从并行系统的角度出发,而不是从顺序平台开始,然后再转向并行。 这项工作得到了计算神经科学计划和神经科学集群的支持(全部在生物中)。 这项工作将重点关注对并行架构和新图形语言的支持。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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James Bower其他文献

The clinical spectrum and natural history of pure akinesia with gait freezing
  • DOI:
    10.1007/s00415-016-8278-x
  • 发表时间:
    2016-09-13
  • 期刊:
  • 影响因子:
    4.600
  • 作者:
    Emily Owens;Keith A. Josephs;Rodolfo Savica;Anhar Hassan;Bryan Klassen;James Bower;Demetrius Maraganore;Joseph Matsumoto;J. E. Ahlskog
  • 通讯作者:
    J. E. Ahlskog
Crystal Structures of Streptomyces Coelicolor Methylmalonyl-CoA Epimerase with Substrate or Transition State Analog Contradicts a Simple General Acid-Base Catalytic Mechanism
天蓝色链霉菌甲基丙二酰辅酶A差向异构酶的晶体结构与底物或过渡态类似物与简单的通用酸碱催化机制相矛盾
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    L. Stunkard;A. Benjamin;James Bower;T. Huth;Jeremy Lohman
  • 通讯作者:
    Jeremy Lohman
Impulse control disorders and use of dopamine agonists in early onset Parkinson’s disease
冲动控制障碍和多巴胺激动剂在早发性帕金森病中的应用
  • DOI:
    10.3389/fneur.2024.1404904
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Pierpaolo Turcano;Jessie Jacobson;Khaled Ghoniem;Aidan F. Mullan;Emanuele Camerucci;Cole Stang;Capucine Piat;James Bower;R. Savica
  • 通讯作者:
    R. Savica

James Bower的其他文献

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{{ truncateString('James Bower', 18)}}的其他基金

CONFERENCE: Travel Support for a Computational Neuroscience Meeting on Realistic Modeling, March 31-April 2, 2005, San Antonio, Texas
会议:2005 年 3 月 31 日至 4 月 2 日,德克萨斯州圣安东尼奥市,为现实建模计算神经科学会议提供差旅支持
  • 批准号:
    0515292
  • 财政年份:
    2005
  • 资助金额:
    $ 79.91万
  • 项目类别:
    Standard Grant
Models of the Cerebellar Purkinje Cell and Cortex
小脑浦肯野细胞和皮质模型
  • 批准号:
    0517572
  • 财政年份:
    2005
  • 资助金额:
    $ 79.91万
  • 项目类别:
    Continuing Grant
Models of the Cerebellar Purkinje Cell and Cortex
小脑浦肯野细胞和皮质模型
  • 批准号:
    0226089
  • 财政年份:
    2001
  • 资助金额:
    $ 79.91万
  • 项目类别:
    Continuing Grant
Models of the Cerebellar Purkinje Cell and Cortex
小脑浦肯野细胞和皮质模型
  • 批准号:
    9986772
  • 财政年份:
    2001
  • 资助金额:
    $ 79.91万
  • 项目类别:
    Continuing Grant
Simulator-Based Neuronal Database
基于模拟器的神经元数据库
  • 批准号:
    0225954
  • 财政年份:
    2001
  • 资助金额:
    $ 79.91万
  • 项目类别:
    Continuing Grant
A General Neural Simulation Systems for Computational Neurobiology
计算神经生物学的通用神经模拟系统
  • 批准号:
    9905410
  • 财政年份:
    2000
  • 资助金额:
    $ 79.91万
  • 项目类别:
    Standard Grant
Travel Support for Annual Computational Neuroscience Meetings, CNS '99, '00, '01; to be held July 1, 1999 -June 30, 2001
年度计算神经科学会议的差旅支持,CNS 99、00、01;
  • 批准号:
    9904727
  • 财政年份:
    1999
  • 资助金额:
    $ 79.91万
  • 项目类别:
    Standard Grant
Simulator-Based Neuronal Database
基于模拟器的神经元数据库
  • 批准号:
    9816615
  • 财政年份:
    1998
  • 资助金额:
    $ 79.91万
  • 项目类别:
    Continuing Grant
Silicon Probes for Multisite Recording in the Nervous System
用于神经系统多点记录的硅探针
  • 批准号:
    9513903
  • 财政年份:
    1996
  • 资助金额:
    $ 79.91万
  • 项目类别:
    Continuing Grant
Support for Annual Computation and Neural Systems Meetings, Monterey, CA, July 11-15, 1995
支持年度计算和神经系统会议,加利福尼亚州蒙特雷,1995 年 7 月 11-15 日
  • 批准号:
    9512763
  • 财政年份:
    1995
  • 资助金额:
    $ 79.91万
  • 项目类别:
    Continuing Grant

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