A General Neural Simulation Systems for Computational Neurobiology

近年来，使用计算机模拟作为检查神经科学中结构/功能关系的一种手段已经显着增长。 越来越多的生理学家，甚至解剖学家正在转向计算机模型，以帮助理解他们收集的生物数据的意义。该项目旨在支持和加强神经元模拟系统GENESIS（通用神经模拟系统）的使用，该系统已在P.I.的实验室工作了十年。 GENESIS目前被全球400多个实验室用作构建不同规模神经生物学模拟的平台。 这笔赠款专门提供资源，以支持这一大批用户，以及改善和扩大访问系统。 在基本用户支助方面，提供了资金，用于进一步扩大在线帮助、网上文件、GENESIS用户组BABEL以及继续编写教育教程。 还为继续扩大GENESIS模拟库提供了支持，这些库提供了完整的模型以及建模组件，可在构建新模型时重复使用。 关于扩大对该系统的访问，我们将重新设计该系统，以支持和加强通过网络以及在个人电脑上的使用。 关于网络，我们将开始对GENESIS界面进行重大重写，但浏览器支持和Java将允许更大的系统访问。 同样，我们将承担GENESIS到Windows平台的PC的主要端口。 PC在学术计算中变得越来越普遍，特别是在教室和实验室。 由于GENESIS一直非常注重将系统用于神经科学教育，因此现在有必要完成PC端口。 当然，我们也将继续保持对UNIX（Linux）的支持。 我们预计，这一努力将大大增加该系统的用户，特别是增加GENESIS在本科和研究生课程的使用。

Project SummaryThe use of computer simulations as a means to examine structure/function relationships in neuroscience has grown dramatically in recent years. A growing number of physiologists and even anatomists are turning to computer models to help understand the significance of the biological data they collect. This project is intended to support and enhance the use of the neuronal simulation system, GENESIS (GEneral NEural SImulation System) that has been developed and supported in the P.I.'s laboratory for the last 10 years. GENESIS is now used by more than 400 laboratories around the world as a platform on which to construct neurobiological simulations at many different levels of scale. This grant specifically provides resources to support this large number of users as well as to improve and expand access to system. With respect to basic user support, funds are provided for further expansion of online-help, web-based documentation, the GENESIS users group BABEL, and for the continued constructions of educational tutorials. Support is also provided to continue to expand the GENESIS simulation libraries, which provide both complete models as well as modeling components for reuse in constructing new models. With respect to expanding access to the system, we will redesign the system to support and enhance use over the web, as well as use on PCs. With respect to the web, we will start a major rewrite of the GENESIS interface will be maintained, however, browser support and java will allow much larger access to the system. Similarly, we will undertake a major port of GENESIS to the Windows platform for PCs. PCs have become ever more prevalent in academic computing, especially in classrooms and laboratories. Because GENESIS has always included a large focus on the use of the system for neuroscience education, it is now necessary to complete the PC port. We will of course continue to maintain our UNIX (Linux) support as well. We anticipate that this effort will substantially add to the users of the system and specifically increase the use of GENESIS in undergraduate and graduate courses.