Integrated Bioprocess Experiments for the Undergraduate Chemical Engineering Curriculum

化学工程本科生课程综合生物过程实验

• 批准号: 9750570
• 负责人: David Odde
• 金额: $ 2.13万
• 依托单位: Michigan Technological University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9750570&HistoricalAwards=false
• 关键词: Integrated; Bioprocess; Experiments; Undergraduate; Chemical

The university was originally established with a vision to support the industries of Michigan and the upper midwest. In the Department of Chemical Engineering, this has meant supporting the traditional chemical processing industries that are vital to the region. Yet, each year chemical engineers enter a marketplace more technically diverse than it was in years past. Today, a greater percentage of chemical engineers are finding employment in the areas of environmental engineering, electronics fabrication, and biochemical processing. To meet this growing diversity, the department has committed substantial resources to a new biochemical engineering emphasis, which was recognized in particular because of both student interest and regional demand for engineers trained in bioprocessing. To initiate this effort, the department has added two new faculty with expertise in biochemical engineering. These faculty have responded by developing new biochemical engineering courses for the students that will provide the needed classroom training. The missing ingredient in the development has clearly been the lack of hands-on, laboratory experience in biochemical engineering. To meet this need, this project establishes a pair of integrated bioprocess engineering experiments that allows students to both produce a biochemical from raw materials and purify it using industrially relevant bioseparation techniques. The new system, L-lysine production by bacterial fermentation and recovery by ion-exchange chromatography, gives students first-hand experience with a complete pilot-scale facility, while also serving to demonstrate the application of chemical and biochemical engineering fundamentals. Thus, the project serves not only the students interested in biochemical engineering but also the students interested in traditional chemical engineering since it provides a unique system for studying chemical process fundamentals such as heat and mass transfer, process control, and chemical kinetics. This project builds on the department's multimillion-dollar chemical processing pilot-plant facilities by integrating a bioprocessing pilot-plant facility. *

该大学最初成立的愿景是支持密歇根州和中西部地区的工业。 在化学工程系，这意味着支持对该地区至关重要的传统化学加工行业。 然而，化学工程师每年进入的市场在技术上比过去几年更加多样化。 今天，更大比例的化学工程师在环境工程，电子制造和生物化学加工领域找到工作。 为了满足这种日益增长的多样性，该部门已承诺大量资源，以一个新的生物化学工程的重点，这是公认的，特别是因为学生的兴趣和区域需求的工程师在生物加工培训。 为了启动这一努力，该部门增加了两个新的教师在生物化学工程的专业知识。 这些教师已经通过为学生开发新的生物化学工程课程来应对，这些课程将提供所需的课堂培训。 开发过程中缺少的因素显然是缺乏生物化学工程方面的实践经验和实验室经验。 为了满足这一需求，该项目建立了一对综合的生物过程工程实验，使学生既可以从原材料中生产生化物质，又可以使用工业相关的生物分离技术对其进行纯化。 新的系统，L-赖氨酸生产细菌发酵和离子交换色谱回收，给学生的第一手经验，一个完整的中试规模的设施，同时也有助于展示化学和生物化学工程基础的应用。 因此，该项目不仅服务于对生物化学工程感兴趣的学生，而且还服务于对传统化学工程感兴趣的学生，因为它提供了一个独特的系统，用于研究化学过程的基本原理，如传热传质，过程控制和化学动力学。 该项目建立在该部门的数百万美元的化学加工中试工厂设施，通过整合生物加工中试工厂设施。 *