Biophotonics: Spatially-Controlled Stem Cell Differentiation by Laser-Guided Direct Writing of Bioactive Materials

生物光子学：通过激光引导直接写入生物活性材料来空间控制干细胞分化

• 批准号: 0119481
• 负责人: David Odde
• 金额: $ 41.31万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0119481&HistoricalAwards=false
• 关键词: Biophotonics; Spatially; Controlled; Stem; Cell

0119481OddeThe objective of this project will be to use LGDW to deliver vascular-endothelial growth factor (VEGF)-coated microspheres to undifferentiated multipotent adult progenitor cells (MAPCs) to induce the endothelial (blood vessel lining) cell phenotype locally. The particle materials to be studied will include polystyrene and polylactic-glycolic acid with sizes ranging from 1-10 um. VEGF will be covalently immobilized to the particles via commercially available surface chemistry.

0119481Odde 该项目的目标是利用 LGDW 将血管内皮生长因子 (VEGF) 包被的微球递送至未分化的多能成体祖细胞 (MAPC)，以诱导局部内皮（血管内壁）细胞表型。 待研究的颗粒材料包括聚苯乙烯和聚乳酸乙醇酸，尺寸范围为1-10微米。 VEGF 将通过市售的表面化学共价固定在颗粒上。