Acquisition of a Preparative Ultracentrifuge
购买制备型超速离心机
基本信息
- 批准号:9808439
- 负责人:
- 金额:$ 4.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-08-01 至 1999-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This award from the Chemistry Research Instrumentation and Facilities Program (CRIF) will assist the Department of Chemistry of SUNY at Stony Brook in acquiring a preparative ultracentrifuge. The areas of chemistry enhanced by the equipment include: (1) the design and characterization of new magnetic contrast agents for magnetic resonance imaging, (2) the synthesis of coenzyme A and palmitoyl-coenzyme A analogs, (3) the folding of the ribosomal protein L9 and of the E3/E1P domain, (4) the role of protein surface loops and hinges in the reactions catalyzed by triosephosphate isomerase and the interfacial enzyme cholesterol oxidase, (5) the binding site for fertilin-beta in its receptor, (6) the synthesis of polyfunctional organosilanes as inhibitors of aspartic and metalloproteases, (7) the study of the interfacial enzyme phospholipase D and (8) the spectroscopic analysis of the molecular forces leading to catalysis in the reactions catalyzed by enoyl-coenzyme A hydratase and enoyl-acp reductase. The instrument will also be used in two advanced undergraduate laboratories. Ultracentrifugation is a technique used mainly to aid in the isolation and purification of proteins. The capability of chemists to carry out cutting edge research in bioorganic chemistry demands access to state-of-the-art preparative ultracentrifuges.
化学研究仪器和设施计划(CRIF)的这一奖项将帮助纽约州立大学石溪分校化学系获得预备性超速离心机。该设备增强的化学领域包括:(1)用于磁共振成像的新的磁共振造影剂的设计和表征,(2)辅酶A和棕榈酰辅酶A类似物的合成,(3)核糖体蛋白L9和E3/E1P结构域的折叠,(4)蛋白质表面环和铰链在磷酸丙糖异构酶和界面酶胆固醇氧化酶催化的反应中的作用,(5)受精素-β在其受体中的结合位置,(6)作为天冬氨酸和金属蛋白酶抑制剂的多官能有机硅烷的合成,(7)界面酶磷脂酶D的研究;(8)Enoyl-辅酶A水合酶和Enoyl-ACP还原酶催化反应中导致催化的分子作用力的光谱分析。该仪器还将用于两个高级本科实验室。超速离心法是一种主要用于帮助分离和纯化蛋白质的技术。化学家在生物有机化学领域进行尖端研究的能力要求获得最先进的制备超速离心机。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Iwao Ojima其他文献
The efficacy of physiological cost index (PCI) measurement of a subject walking with an Intelligent Prosthesis
使用智能假肢行走的受试者的生理成本指数 (PCI) 测量效果
- DOI:
10.3109/03093649909071609 - 发表时间:
1999 - 期刊:
- 影响因子:1.5
- 作者:
T. Chin;S. Sawamura;H. Fujita;S. Nakajima;Iwao Ojima;H. Oyabu;Y. Nagakura;H. Otsuka;A. Nakagawa - 通讯作者:
A. Nakagawa
Taxane Anticancer Agents Basic Science and Current Status
紫杉烷类抗癌药物基础科学及现状
- DOI:
- 发表时间:
1994 - 期刊:
- 影响因子:0
- 作者:
Gunda I Georg;Thomas T. Chen;Iwao Ojima;D. Vyas - 通讯作者:
D. Vyas
Synthesis and biological evaluation of biotin conjugates of (±)-(4b<em>S</em>,8a<em>R</em>,10a<em>S</em>)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets
- DOI:
10.1016/j.bmcl.2013.08.058 - 发表时间:
2013-10-15 - 期刊:
- 影响因子:
- 作者:
Akira Saito;Maureen Higgins;Suqing Zheng;Wei Li;Iwao Ojima;Albena T. Dinkova-Kostova;Tadashi Honda - 通讯作者:
Tadashi Honda
Drug Resistance Mechanisms and Novel Drug Targets for Tuberculosis Therapy
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:5.9
- 作者:
Md Mahmudul Islam;H.M.Adman Hameed;Julius Mugweru;Chiranjibi Chhotaray;Changwei Wang;Yaoju Tan;Jianxiong Liu;Xinjie Li;Shouyong Tan;Iwao Ojima;Wing Wai Yew;Eric Nuermberger;Gyanu Lamichhane;Tianyu Zhang - 通讯作者:
Tianyu Zhang
Iwao Ojima的其他文献
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{{ truncateString('Iwao Ojima', 18)}}的其他基金
New Methods in Catalytic Organic Synthesis with Transition Metal Complexes
过渡金属配合物催化有机合成新方法
- 批准号:
0809315 - 财政年份:2008
- 资助金额:
$ 4.11万 - 项目类别:
Continuing Grant
New Methods in Catalytic Organic Synthesis with Transition Metal Complexes
过渡金属配合物催化有机合成新方法
- 批准号:
0516797 - 财政年份:2005
- 资助金额:
$ 4.11万 - 项目类别:
Continuing Grant
Purchase of a 400 MHz NMR Spectrometer
购买 400 MHz 核磁共振波谱仪
- 批准号:
0131146 - 财政年份:2002
- 资助金额:
$ 4.11万 - 项目类别:
Standard Grant
New Methods in Catalytic Organic Synthesis with Transition Metal Complexes
过渡金属配合物催化有机合成新方法
- 批准号:
0213216 - 财政年份:2002
- 资助金额:
$ 4.11万 - 项目类别:
Continuing Grant
U.S.-Japan Cooperative Science: Experimental and Theoretical Studies on Stucture and Catalytic Activity of di- and Polynuclear Metal Complexes
美日合作科学:双核和多核金属配合物结构和催化活性的实验和理论研究
- 批准号:
9726789 - 财政年份:1998
- 资助金额:
$ 4.11万 - 项目类别:
Standard Grant
Synthetic and Mechanistic Studies on the Homogeneous Catalysis of Transition Metal Complexes
过渡金属配合物的均相催化合成及机理研究
- 批准号:
9710504 - 财政年份:1997
- 资助金额:
$ 4.11万 - 项目类别:
Continuing Grant
Acquisition of a Fluorescence Spectrometer for Research in Protein Catalysis and Folding
购买荧光光谱仪用于蛋白质催化和折叠研究
- 批准号:
9709164 - 财政年份:1997
- 资助金额:
$ 4.11万 - 项目类别:
Standard Grant
Synthetic and Mechanistic Studies on the Homogeneous Catalysis of Transition Metal Complexes
过渡金属配合物的均相催化合成及机理研究
- 批准号:
9400808 - 财政年份:1994
- 资助金额:
$ 4.11万 - 项目类别:
Continuing Grant
Synthetic and Mechanistic Studies on the Homogeneous Catalysis of Transition Metal Complexes
过渡金属配合物的均相催化合成及机理研究
- 批准号:
9103765 - 财政年份:1991
- 资助金额:
$ 4.11万 - 项目类别:
Continuing Grant
Synthetic and Mechanistic Studies on the Homogenous Catalysis of Transition Metal Complexes (Chemistry)
过渡金属配合物均相催化的合成及机理研究(化学)
- 批准号:
8721972 - 财政年份:1988
- 资助金额:
$ 4.11万 - 项目类别:
Continuing Grant
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