Acquisition of a Preparative Ultracentrifuge

该奖项由化学研究仪器和设施 计划（CRIF）将协助纽约州立大学化学系在斯托尼 布鲁克获得了一个预备性的超浓缩铀。 化学领域 增强的设备包括：（1）设计和表征 新的磁共振造影剂，（2） 辅酶A和棕榈酰辅酶A类似物的合成，（3）核糖体蛋白L9和E3/E1 P结构域的折叠，（4） 蛋白质表面环和铰链在催化的反应， 磷酸丙糖异构酶和界面酶胆固醇氧化酶， (5)受精素-β在其受体中的结合位点，（6）合成 多官能有机硅烷作为天冬氨酸和 金属蛋白酶;（7）磷脂酶D的研究 和（8）分子力的光谱分析， 在烯酰辅酶A水合酶催化的反应中的催化作用， 烯酰-ACP还原酶 该仪器还将用于两个先进的 本科生实验室 超离心是一种技术， 主要用于帮助分离和纯化蛋白质。 的 化学家进行生物有机前沿研究的能力 化学需要最先进的制备方法 超浓缩的

This award from the Chemistry Research Instrumentation and Facilities Program (CRIF) will assist the Department of Chemistry of SUNY at Stony Brook in acquiring a preparative ultracentrifuge. The areas of chemistry enhanced by the equipment include: (1) the design and characterization of new magnetic contrast agents for magnetic resonance imaging, (2) the synthesis of coenzyme A and palmitoyl-coenzyme A analogs, (3) the folding of the ribosomal protein L9 and of the E3/E1P domain, (4) the role of protein surface loops and hinges in the reactions catalyzed by triosephosphate isomerase and the interfacial enzyme cholesterol oxidase, (5) the binding site for fertilin-beta in its receptor, (6) the synthesis of polyfunctional organosilanes as inhibitors of aspartic and metalloproteases, (7) the study of the interfacial enzyme phospholipase D and (8) the spectroscopic analysis of the molecular forces leading to catalysis in the reactions catalyzed by enoyl-coenzyme A hydratase and enoyl-acp reductase. The instrument will also be used in two advanced undergraduate laboratories. Ultracentrifugation is a technique used mainly to aid in the isolation and purification of proteins. The capability of chemists to carry out cutting edge research in bioorganic chemistry demands access to state-of-the-art preparative ultracentrifuges.