New Methods in Catalytic Organic Synthesis with Transition Metal Complexes

过渡金属配合物催化有机合成新方法

• 批准号: 0516797
• 负责人: Iwao Ojima
• 金额: $ 42万
• 依托单位: SUNY at Stony Brook
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0516797&HistoricalAwards=false
• 关键词: New; Methods; Catalytic; Organic; Synthesis

This project addresses the development of new and efficient carbocyclization and higher order cycloaddition reactions, providing synthetic routes to appropriately functionalized polycyclic intermediates for the syntheses of bioactive natural and unnatural products. Novel fine-tunable monodentate phosphorus ligands and their applications to highly efficient catalytic asymmetric reactions and processes will also be explored. Particular attention will be placed on "green chemistry" concepts, including high selectivity and "atom economy" as well as the highly efficient separation and recovery of catalyst species, through the development of fluorous catalyst systems.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Iwao Ojima of the Department of Chemistry at the State University of New York at Stony Brook. One of the most fascinating goals in catalysis is to create effective catalyst systems that can promote multi-step reactions giving useful chemical substances, including those with multiple chiral centers, from simple starting materials. These catalyst systems should also promote the reactions with extremely high turnover frequency as well as turnover number and/or with highly efficient catalyst recovery and reuse without environmental concerns. Professor Ojima and his students are designing and developing new and efficient catalytic organic reactions incorporating (poly)cyclizations and carbonylations as key unit reactions, which provide useful synthetic methods for organic syntheses.

该项目致力于开发新的和有效的碳环化和高阶环加成反应，为生物活性天然和非天然产物的合成提供适当官能化的多环中间体的合成路线。本课程也将探讨新颖的可微调单齿磷配体及其在高效催化不对称反应和过程中的应用。特别关注“绿色化学”概念，包括高选择性和“原子经济性”，以及通过开发氟催化剂系统高效分离和回收催化剂物种。通过这一更新奖项，有机和高分子化学计划支持纽约州立大学斯托尼布鲁克分校化学系的Iwao Ojima博士的研究。催化领域最令人着迷的目标之一是创造有效的催化剂体系，该体系可以促进多步反应，从简单的起始原料中产生有用的化学物质，包括具有多个手性中心的化学物质。这些催化剂体系还应当促进具有极高的周转频率和周转次数和/或具有高效的催化剂回收和再利用而没有环境问题的反应。大岛教授和他的学生正在设计和开发新的和有效的催化有机反应，其中包括（聚）环化和羰基化作为关键单元反应，这为有机合成提供了有用的合成方法。