Purchase of a 400 MHz NMR Spectrometer

购买 400 MHz 核磁共振波谱仪

• 批准号: 0131146
• 负责人: Iwao Ojima
• 金额: $ 26.25万
• 依托单位: SUNY at Stony Brook
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0131146&HistoricalAwards=false
• 关键词: Purchase; 400; MHz; NMR; Spectrometer

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the State University of New York in Stony Brook will acquire a 400 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on a) the development of synthetic processes based on organometallic catalysts and the development of synthetic methods for natural products and their congeners (Ojima); b) synthesis of biologically active natural products and designed molecular probes (Parker); c) synthesis of analogues of Coenzyme A and development of computer-designed receptors and sensors for biological molecules (Drueckhammer); d) investigations on the role of disintegrins in mammalian fertilization and on understanding enzyme motion (Sampson); e) the structure and reactivity of all-carbon molecules (Goroff); and f) the preparation of designed supramolecular structures (Fowler). Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including biochemistry, biological sensor development, and materials chemistry.

根据化学研究仪器和设施（CRIF）项目的合同，纽约州立大学石溪分校化学系将获得一台400 MHz核磁共振光谱仪。该设备将使研究人员能够开展以下研究：a)开发基于有机金属催化剂的合成工艺和开发天然产物及其同系物的合成方法（Ojima）；b)生物活性天然产物的合成和设计的分子探针（Parker）；c)辅酶A类似物的合成和计算机设计的生物分子受体和传感器的开发（Drueckhammer）；d)崩解素在哺乳动物受精中的作用和对酶运动的理解的研究（Sampson）；e)全碳分子的结构和反应性（Goroff）；f)制备设计的超分子结构（Fowler）。核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果将对包括生物化学、生物传感器开发和材料化学在内的许多领域产生影响。