New Methods in Catalytic Organic Synthesis with Transition Metal Complexes

过渡金属配合物催化有机合成新方法

• 批准号: 0809315
• 负责人: Iwao Ojima
• 金额: $ 44.1万
• 依托单位: SUNY at Stony Brook
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0809315&HistoricalAwards=false
• 关键词: New; Methods; Catalytic; Organic; Synthesis

This project will continue and expand the ongoing investigation on new and efficient higher order cycloaddition and cyclohydrocabonylation reactions. These reactions allow for constructing multiple bonds all at once and for converting linear starting materials to polycyclic compounds in one step. In addition, the fine-tunable phosphorus ligands developed successfully in the last funding period will be applied to the development of highly efficient catalytic asymmetric reactions that are useful for the synthesis of enantiomerically pure compounds. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Iwao Ojima of the Department of Chemistry at the State University of New York at Stony Brook. Professor Ojima's research efforts revolve around the discovery of highly efficient catalytic methodology for the rapid construction of polycyclic and enantiomerically pure compounds. These compounds are of significant biological and medicinal importance. In addition, the proposed chemistry is green in nature, as it has high selectivity and generates little waste materials.

该项目将继续和扩大正在进行的新的和有效的高阶环加成和环氢化羰基化反应的研究。 这些反应允许同时构建多个键，并在一个步骤中将线性起始材料转化为多环化合物。 此外，在上一个资助期内成功开发的可微调磷配体将用于开发高效催化不对称反应，这些反应可用于合成对映体纯化合物。有了这个奖项，有机和高分子化学计划是支持教授Iwao Ojima的化学系在州立大学的纽约在斯托尼布鲁克的研究。 大岛教授的研究工作围绕着发现高效的催化方法，用于快速构建多环和对映体纯化合物。 这些化合物具有重要的生物学和医学意义。 此外，所提出的化学性质是绿色的，因为它具有高选择性并且产生很少的废料。