New Methods in Catalytic Organic Synthesis with Transition Metal Complexes

过渡金属配合物催化有机合成新方法

• 批准号: 0213216
• 负责人: Iwao Ojima
• 金额: $ 41.7万
• 依托单位: SUNY at Stony Brook
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0213216&HistoricalAwards=false
• 关键词: New; Methods; Catalytic; Organic; Synthesis

The research is focused in two connected directions. First, new carbonylative carbotricyclizations and related reactions will be developed. The method provides an efficient method for the production of fused polycyclic systems. Second, enantioselective and regioselective hydrocarbonylation reactions will be carried out with fluorous catalysis using fluorinated solvents and with fluorous catalysis using supercritical carbon dioxide. The prospects are high for developing methodology wherein catalyst recovery and reuse are possible, thereby leading to practical green chemistry. With this award, the Organic and Macromolecular Chemistry Program is supporting the research efforts of Dr. Iwao Ojima of the Department of Chemistry at SUNY, Stony Brook. Professor Ojima will focus his work on developing methodology to affect carbocyclization and carbonylation reactions. He will also develop green chemistry in catalytic organic synthesis promoted by transition metal catalysts. The research has broader impact for the training of students and for use in the pharmaceutical and agricultural industries. Collaboration between academia and industry are already in place.

研究集中在两个相互关联的方向。 首先，将开发新的羰基化碳三环化反应及相关反应。 该方法为制备稠合多环体系提供了一种有效的方法。 第二，对映选择性和区域选择性的加氢羰基化反应将使用氟化溶剂用氟催化剂和使用超临界二氧化碳用氟催化剂进行。 开发催化剂回收和再利用的方法，从而导致实用的绿色化学的前景是高的。有了这个奖项，有机和高分子化学计划是支持博士的研究工作的岩尾大岛化学系在纽约州立大学，斯托尼布鲁克。 教授大岛将专注于他的工作发展的方法，影响碳环化和羰基化反应。 他还将在过渡金属催化剂促进的催化有机合成中发展绿色化学。 该研究对学生的培训以及在制药和农业行业的使用具有更广泛的影响。 学术界和工业界之间的合作已经到位。