New Methods in Catalytic Organic Synthesis with Transition Metal Complexes

这项研究集中在两个相互关联的方向。首先，将开发新的碳化碳三环化反应和相关反应。该方法为生产稠合多环体系提供了一种有效的方法。其次，对映体选择性和区域选择性的烃化反应将在氟化溶剂的氟催化和超临界二氧化碳的氟催化下进行。开发催化剂回收和再利用的方法学前景广阔，从而导致实用的绿色化学。通过这一奖项，有机和高分子化学项目正在支持纽约州立大学石溪分校化学系的Iwao Ojima博士的研究努力。Ojima教授将把他的工作重点放在开发影响碳环化和羰化反应的方法上。他还将在过渡金属催化剂促进的催化有机合成方面发展绿色化学。这项研究对学生的培训以及在制药和农业行业的使用具有更广泛的影响。学术界和产业界之间的合作已经到位。

The research is focused in two connected directions. First, new carbonylative carbotricyclizations and related reactions will be developed. The method provides an efficient method for the production of fused polycyclic systems. Second, enantioselective and regioselective hydrocarbonylation reactions will be carried out with fluorous catalysis using fluorinated solvents and with fluorous catalysis using supercritical carbon dioxide. The prospects are high for developing methodology wherein catalyst recovery and reuse are possible, thereby leading to practical green chemistry. With this award, the Organic and Macromolecular Chemistry Program is supporting the research efforts of Dr. Iwao Ojima of the Department of Chemistry at SUNY, Stony Brook. Professor Ojima will focus his work on developing methodology to affect carbocyclization and carbonylation reactions. He will also develop green chemistry in catalytic organic synthesis promoted by transition metal catalysts. The research has broader impact for the training of students and for use in the pharmaceutical and agricultural industries. Collaboration between academia and industry are already in place.