GOALI: ICD Transvenous Lead Placement: An Active Bidomain Heart/Torso Simulation Study of Defibrillation Efficacy

GOALI：ICD 经静脉引线置入：除颤功效的主动双域心脏/躯干模拟研究

• 批准号: 9809132
• 负责人: Natalia Trayanova
• 金额: $ 22万
• 依托单位: Tulane University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 2003-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9809132&HistoricalAwards=false
• 关键词: GOALI; ICD; Transvenous; Lead; Placement

9809132 Trayanova The objective of this research is the development of a novel model of the electrical activity of the fibrillating myocardium with the objective of optimizing lead placement for defibrillation. The model is novel in the use of a biodomain approach which incorporates both extra and intra- cellular ionic currents as well as the active membrane behavior. The model also takes into account the orientation and structure of the muscle fibers making up the myocardium, something which the investigator has discovered has an important bearing on the electrical activity induced by defibrillating currents. The fiber structure is to be taken from a detailed map of myocardial fiber orientation derived in New Zealand. Model validation is to be carried out with ongoing experimental work being done in the investigator's lab. This research is in collaboration with a company, Pacesetter, Inc., an industry leader in the design and manufacture of cardiac rhythm management devices. ***

9809132 Trayanova本研究的目的是开发一种新的心肌电活动模型，旨在优化除颤电极导线的放置。 该模型是新颖的，在使用的生物结构域的方法，它结合了细胞外和细胞内的离子电流，以及主动膜行为。 该模型还考虑了构成心肌的肌纤维的方向和结构，研究人员发现这对由电流引起的电活动有重要影响。 纤维结构取自新西兰心肌纤维定向的详细图。 模型验证将在研究人员实验室进行的持续实验工作中进行。 这项研究是与一家名为Pacesetter，Inc.的公司合作进行的，心律管理设备设计和制造的行业领导者。 ***