Shock-Induced Arrhythmogenesis in Regional Myocardial Ischemia

局部心肌缺血中电击诱发的心律失常

• 批准号: 0601935
• 负责人: Natalia Trayanova
• 金额: $ 34.41万
• 依托单位: Tulane University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0601935&HistoricalAwards=false
• 关键词: Shock; Induced; Arrhythmogenesis; Regional; Myocardial

0601935TrayanovaThis project will improve the understanding of defibrillation mechanisms in the context of ischemia. Since a large fraction of cardiac arrhythmias occur in this setting, this is a significant clinical problem. The goal of this proposal is to develop a 3-D model of the rabbit ventricle and to study how the response of the heart to defibrillation shocks is altered by ischemia. This project could have an impact in the development of better defibrillators to prevent sudden cardiac death.

0601935Trayanova该项目将提高对缺血背景下除颤机制的理解。 由于大部分心律失常发生在这种情况下，这是一个重要的临床问题。该提案的目标是开发兔子心室的3D模型，并研究心脏对除颤电击的反应如何因缺血而改变。 该项目可能会对开发更好的心脏起搏器以预防心脏性猝死产生影响。